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Study Title and Description

Evaluation of diagnostic tests for Clostridium difficile infection.



Key Questions Addressed
1 Key Question 1 - Summary of matched comparisons of select assays for C. difficile toxins
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Primary Publication Information
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TitleData
Title Evaluation of diagnostic tests for Clostridium difficile infection.
Author Swindells J., Brenwald N., Reading N., Oppenheim B.
Country Department of Microbiology, City Hospital, Dudley Road, Birmingham, United Kingdom.
Year 2010
Numbers Pubmed ID: 20032256

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Summary of matched comparisons of select assays for C. difficult toxins (Table C1)
Design Details
Question... Follow Up Answer Follow-up Answer
Patients/ Site n=unknown Patients over 65 yrs old who developed diarrhea at least 48 hrs after admission Birmingham City Hospital, UK Unknown spectrum Unknown selection
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Tested Specimens n=150 fresh liquid stool specimens stored < 48 hrs at 2-8 o C ; Independent, blinded operators; No tests were repeated
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Reference Standard/ % Positive in Sample Toxigenic culture using CTA on cultured organisms 12.0%
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Tests Compared GeneOhm C. difficile (tcdB), Becton Dickinson GeneXpert C.difficile (tcdB), Cepheid VIDAS C. difficile Tox A/B, bioMerieux
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PPV/ NPV GeneOhm C. difficile (tcdB), Becton Dickinson PPV 17/18=94.4% NPV 131/132=99.2% GeneXpert C.difficile (tcdB), Cepheid PPV 18/19=94.7% NPV 131/131=100% VIDAS C. difficile Tox A/B, bioMerieux PPV 8/8=100% NPV 132/142=93.0%
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True Positive/ False Positive‡ GeneOhm C. difficile (tcdB), Becton Dickinson True Positive 17/18=94.4% False Positive 1/132=0.8% GeneXpert C.difficile (tcdB), Cepheid True Positive 18/18=100% False Positive 1/132=0.8% VIDAS C. difficile Tox A/B, bioMerieux True Positive 8/18=44.4% False Positive 0/132=0%
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Results & Comparisons

No Results found.