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Study Title and Description

Comparison of three commercial methods for rapid detection of Clostridium difficile toxins A and B from fecal specimens.



Key Questions Addressed
1 Key Question 1 - Summary of matched comparisons of select assays for C. difficile toxins
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Primary Publication Information
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TitleData
Title Comparison of three commercial methods for rapid detection of Clostridium difficile toxins A and B from fecal specimens.
Author Alcalá L., Sánchez-Cambronero L., Catalán MP., Sánchez-Somolinos M., Peláez MT., Marín M., Bouza E.
Country Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Avda. Dr. Esquerdo, 46, 28007 Madrid, Spain. luisalcala@efd.net
Year 2008
Numbers Pubmed ID: 18784313

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Summary of matched comparisons of select assays for C. difficult toxins (Table C1)
Design Details
Question... Follow Up Answer Follow-up Answer
Patients/ Site n=305 mixture of suspected CDI and positive samples by CTA; Hospital General Universitario Gregorio Maranon, Madrid, Spain Unknown spectrum Unknown selection
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Tested Specimens n=367 fresh refrigerated; Unknown consistency Unknown blinded Unknown indeterminate results
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Reference Standard/ % Positive in Sample CTA of specimen and cultured organisms when direct CTA was negative 27.8%
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Tests Compared ImmunoCard Toxins A&B, Meridian Xpect C. diff. toxin A/B, Remel TOX A/B QUIK CHEK, Techlab
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PPV/ NPV ImmunoCard Toxins A&B, Meridian PPV 68/81=83.9% NPV 252/265=88.1% Xpect C. diff. toxin A/B, Remel PPV 50/61=81.9% NPV 254/306=83.0% TOX A/B QUIK CHEK, Techlab PPV 56/68=82.4% NPV 253/299=84.6%
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True Positive/ False Positive‡ ImmunoCard Toxins A&B, Meridian True Positive 68/102=66.7% False Positive 13/265=4.9% Xpect C. diff. toxin A/B, Remel True Positive 50/102=49.0% False Positive 11/265=4.2% TOX A/B QUIK CHEK, Techlab True Positive 56/102=54.9% False Positive 12/265=4.5%
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Results & Comparisons

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