Study Title and Description
Six rapid tests for direct detection of Clostridium difficile and its toxins in fecal samples compared with the fibroblast cytotoxicity assay.
Key Questions Addressed
|1||Key Question 1 - Summary of matched comparisons of select assays for C. difficile toxins|
Primary Publication Information
|Title||Six rapid tests for direct detection of Clostridium difficile and its toxins in fecal samples compared with the fibroblast cytotoxicity assay.|
|Author||Turgeon DK., Novicki TJ., Quick J., Carlson L., Miller P., Ulness B., Cent A., Ashley R., Larson A., Coyle M., Limaye AP., Cookson BT., Fritsche TR.|
|Country||Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington 98195-7110, USA.|
Pubmed ID: 12574264
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 1 - Summary of matched comparisons of select assays for C. difficult toxins (Table C1)
|Question... Follow Up||Answer||Follow-up Answer|
|Patients/ Site||n=1003 Consecutive samples, all suspected CDI; Childrens, university & cancer centers in Seattle, WA; 45% stem cell transplant patients Unknown spectrum Unknown selection|
|Tested Specimens||n=1003 any consistency; fresh for CTA, rest frozen at -20o C; Unknown interim time Unknown blinded Unknown indeterminate results|
|Reference Standard/ % Positive in Sample||CTA 10.1%|
|Tests Compared||Premier Cytoclone A/B, Meridian C. diff Tox A/B, Techlab|
|PPV/ NPV||Premier Cytoclone A/B, Meridian PPV 74/82=90.2% NPV 890/917=97.1% C. diff Tox A/B, Techlab PPV 78/83=94.0% NPV 897/902=99.4%|
|True Positive/ False Positive‡||Premier Cytoclone A/B, Meridian True Positive 74/101=73.3% False Positive 8/898=0.9% C. diff Tox A/B, Techlab True Positive 78/101=77.2% False Positive 5/902=0.6%|
Results & Comparisons
No Results found.