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Study Title and Description

Evaluation of methods for detection of toxins in specimens of feces submitted for diagnosis of Clostridium difficile-associated diarrhea.



Key Questions Addressed
1 Key Question 1 - Summary of matched comparisons of select assays for C. difficile toxins
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Primary Publication Information
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TitleData
Title Evaluation of methods for detection of toxins in specimens of feces submitted for diagnosis of Clostridium difficile-associated diarrhea.
Author O'Connor D., Hynes P., Cormican M., Collins E., Corbett-Feeney G., Cassidy M.
Country Microbiology Laboratory, Portiuncula Hospital, Ballinasloe, County Galway, Galway, Ireland. labmanager@portiuncula.com
Year 2001
Numbers Pubmed ID: 11474001

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Summary of matched comparisons of select assays for C. difficult toxins (Table C1)
Design Details
Question... Follow Up Answer Follow-up Answer
Patients/ Site n=133 Adults, consecutive samples, CDI suspected; Multiple health centers in Galway County area of Ireland Unknown spectrum Unknown selection
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Tested Specimens n=200 92% liquid or unformed; -20o C for CTA, then frozen at 84o C; Unknown blinded
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Reference Standard/ % Positive in Sample CTA 30.5%
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Tests Compared Premier Toxins A&B, Meridian C. diff Tox A/B II, Techlab
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PPV/ NPV Premier Toxins A&B, Meridian PPV 50/51=98.0% NPV 138/149=92.6% C. diff Tox A/B II, Techlab PPV 49/50=98.0% NPV 138/150=92.0%
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True Positive/ False Positive‡ Premier Toxins A&B, Meridian True Positive 50/61=82.0% False Positive 1/139=0.7% C. diff Tox A/B II, Techlab True Positive 49/61=80.3% False Positive 1/139=0.7%
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Results & Comparisons

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