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Study Title and Description

Predicting Clostridium difficile toxin in hospitalized patients with antibiotic-associated diarrhea.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Predicting Clostridium difficile toxin in hospitalized patients with antibiotic-associated diarrhea.
Author Peled N., Pitlik S., Samra Z., Kazakov A., Bloch Y., Bishara J.
Country Institute of Pulmonology, Rabin Medical Center, Beilinson Hospital, Israel.
Year 2007
Numbers Pubmed ID: 17385141

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective cohort study
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Objective Compare the clinical characteristics of patients who developed CDI versus patients with a negative stool assay for C. difficile toxin
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Population 217 patients with ADD. C. difficile toxin positive (n=52): n=52; mean age 72 years; Male-female ratio 1:26 C. difficile toxin negative (n=165): mean age 66 (p=0.21 vs. toxin pos.); Male-female ratio 1:11
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Methods Diarrhea was defined as the passage of •3 unformed stools for •2 consecutive days. Toxin assay: enzyme immunoassay for C. difficile toxin A/B (TechLab). Analysis (controlling for confounding): Stepwise logistic regression
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Results Significant factors for CDI: watery diarrhea (OR=17.1, p=0.000), functional capacity score of 2 or 3 (requiring assistance in daily activities or bedridden) (OR=9.14, p=0.000), use of a proton pump inhibitor (OR=6.1, p=0.024), hypoalbuminemia (OR=3.8, p=0.001), histamine blocker (OR=3.1, p=0.024) leukocytosis (OR=2.7, p=0.004). Stepwise logistic regression analysis predicted a positive result for C. difficile toxin with 95% specificity and 68% sensitivity.
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Study Origin Israel
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use NE
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General Antibiotic Use NE
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Health Status or Disease Severity Functional capacity score OR = 9.1
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Acid Suppression PPI OR = 6.1 Histamine blocker OR = 3.1
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Hospitalization in an ICU NE
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Age NE
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Miscellaneous Hypoalbuinemia OR = 3.8 Leukocytosis OR = 2.7
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Results & Comparisons

No Results found.