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Study Title and Description

Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposure.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposure.
Author Samore MH., Venkataraman L., DeGirolami PC., Merrigan MM., Johnson S., Gerding DN., Carmeli Y., Harbarth S.
Country VA Salt Lake City Health Care System, and Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. Matthew.Samore@hsc.utah.edu
Year 2006
Numbers Pubmed ID: 16584304

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective case series
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Objective Analyze C. difficile susceptibility results and genotypes in relation to antibiotic exposures that precipitated CDI
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Population 83 patients with nosocomial CDI. Mean age 66 years; female 43% Median length of stay before onset of CDI was 10 days (range, 2-95). C. difficile isolates were recovered from patients in 10 different hospital wards and 3 intensive care units. The wards with the largest number of cases were vascular surgery (n=15) and general surgery/liver transplantation (n =14).
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Methods Prospective surveillance and collection of stool isolates. Isolates were genotyped by pulsed-field gel electrophoresis and restriction enzyme analysis. Analysis: multivariable logistic regression
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Results Clindamycin exposure was strongly associated with CDI caused by isolates that exhibited multiple resistance to clindamycin, erythromycin, and trovafloxacin (prevalence OR 4.2; 95%CI: 1.1 to 16.8)
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Study Origin United States
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use Clindamycin OR = 4.2
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General Antibiotic Use NE
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Health Status or Disease Severity NE
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Acid Suppression NE
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Hospitalization in an ICU NE
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Age NE
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Miscellaneous
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Results & Comparisons

No Results found.