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Study Title and Description

Proton pump inhibitor therapy is a risk factor for Clostridium difficile-associated diarrhoea.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Proton pump inhibitor therapy is a risk factor for Clostridium difficile-associated diarrhoea.
Author Yearsley KA., Gilby LJ., Ramadas AV., Kubiak EM., Fone DL., Allison MC.
Country Department of Adult Medicine, Royal Gwent Hospital, Newport, South Wales, UK.
Year 2006
Numbers Pubmed ID: 16907893

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective case-control
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Objective Association between acid suppression therapy and risk of CDI
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Population N=308 hospital inpatients. CDI group (n=155): Mean age 79 years (range 37- 102); Female 61% Received antibiotics: 92% Received PPI: 40% Received acid suppression: 41% Control group (n=153): Mean age 79 years (range 43-99); female 55% Received antibiotics: 50%, p<001 (vs. case) Received PPI: 25%, p=0.004 Received acid suppression: 26%, p=0.005
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Methods Cases with CDI were mostly were recruited from general medical wards. Control was chosen as a person on the same ward whose birthday was closest to that of the index patient. Analysis: Logistic regression
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Results CDI was independently associated with: antibiotic use (OR 13.1, 95%CI: 6.6 to 26.1); acid suppression therapy (OR 1.90, 95%CI: 1.10 to 3.29); and female gender (OR 1.79, 95%CI: 1.06 to 3.04).
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Study Origin United Kingdom
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use NE
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General Antibiotic Use OR = 13.1
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Health Status or Disease Severity NE
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Acid Suppression OR = 1.90
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Hospitalization in an ICU NE
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Age NS
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Miscellaneous Female gender OR = 1.79
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Results & Comparisons

No Results found.