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Study Title and Description

Specific risk factors for Clostridium difficile-associated diarrhea: a prospective, multicenter, case control evaluation.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Specific risk factors for Clostridium difficile-associated diarrhea: a prospective, multicenter, case control evaluation.
Author Vesta KS., Wells PG., Gentry CA., Stipek WJ.
Country University of Oklahoma College of Pharmacy, Oklahoma City, OK 73190-5040, USA. Kimi.Vesta@ouhsc.edu
Year 2005
Numbers Pubmed ID: 16216661

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective observational case control, multicenter, study
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Objective Risk factors associated with the development of nosocomial CDI, particularly with the use of antibiotics
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Population 144 hospitalized patients with diarrhea requiring a C. difficile toxin test as part of their routine clinical workup, Cases (n=72) Mean age 56 years; Female 43% Controls (n=72) Mean age 56 years; Female 43%
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Methods Case patients had nosocomial diarrhea and positive C. difficile toxin tests. Control were patients with stool negative for C. difficile toxin and were individually matched with cases based on hospital, sex, age (within 4 years), and duration of hospital stay up to the time of stool sampling (within 4 days). Analysis: multivariate logistic regression analysis to identify independent risk factors for the development of CDI (not performed)
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Results There were no significant differences in antibiotic use between cases and controls. Patient severity, classified by Horn’s Index, was significantly different between cases and controls (p=0.0022).
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Study Origin United States
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use NE
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General Antibiotic Use NS
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Health Status or Disease Severity Horn’s Index P = 0.0022
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Acid Suppression NE
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Hospitalization in an ICU NE
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Age NS
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Miscellaneous
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Results & Comparisons

No Results found.