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Study Title and Description

Clostridium difficile-associated diarrhea in a VA medical center: clustering of cases, association with antibiotic usage, and impact on HIV-infected patients.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Clostridium difficile-associated diarrhea in a VA medical center: clustering of cases, association with antibiotic usage, and impact on HIV-infected patients.
Author Mody LR., Smith SM., Dever LL.
Country Department of Medicine, Veterans Affairs New Jersey Health Care System, East Orange, USA.
Year 2001
Numbers Pubmed ID: 11198022

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective case control
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Objective Evaluate risk factors and clustering of CDI cases over 2 years
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Population 252 patients from a Veterans Affairs Medical Center with unformed stools and positive stool C difficile cytotoxin assays over the 24-month period; 98 patients served as control. No information on age. 45 cases (17.8%) and 19 controls (19.4%) were HIV-infected.
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Methods Cases were patients with CDI. Controls were patients with unformed stools and C. difficile negative toxin test. Stools for cytotoxin assays were frozen and sent on ice to a reference laboratory. Analysis: logistic regression
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Results Third-generation cephalosporins were the antibiotics most strongly associated with CDI (OR 3.63 95%CI 1.56 to 9.80). The association of third-generation cephalosporin use was particularly striking in HIV- infected patients (p=0.0004 when HIV status was included in the model). 34 (76%) of 45 HIV- infected patients with CDI died during their hospitalization.
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Study Origin United States
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use 3rd generation cephalosporins OR = 3.6
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General Antibiotic Use NE
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Health Status or Disease Severity NE
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Acid Suppression NE
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Hospitalization in an ICU NE
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Age NE
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Miscellaneous
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Results & Comparisons

No Results found.