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Study Title and Description

Factors associated with nosocomial diarrhea and Clostridium difficile-associated disease on the adult wards of an urban tertiary care hospital.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Factors associated with nosocomial diarrhea and Clostridium difficile-associated disease on the adult wards of an urban tertiary care hospital.
Author Schwaber MJ., Simhon A., Block C., Roval V., Ferderber N., Shapiro M.
Country Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, Jerusalem, Israel.
Year 2000
Numbers Pubmed ID: 11699546

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective case control
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Objective Determine factors associated with the development of nosocomial diarrhea and the acquisition of CDI
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Population 136 hospital inpatients, 98 with nosocomial diarrhea and 38 controls. 59.9 +17.5 years, whereas that of the controls was 56.3 +19.9 years Clostridium difficile toxin B was identified in the stool of 13 cases.
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Methods Diarrhea defined as •3 loose or watery stools in a 24 h, lasting for • 3 days, beginning • 2 days after admission. Toxin assay: cell-culture cytotoxin test in a culture of human fibroblasts. Analysis: No multivariate analyses reported.
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Results Factors associated with the presence of C. difficile toxin B as compared to other causes of nosocomial diarrhea were: greater number of individual antibiotics used during hospitalization (p=0.02); cephalosporin use (p=0.03), more specifically, a third generation cephalosporin (p=0.02). Among patients with nosocomial diarrhea, those who C. difficile toxin positive had a significantly higher total antibiotic burden (as antibiotic days) than those with diarrhea due to other causes (p=0.01).
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Study Origin Israel
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
No arms have been defined in this extraction form.

Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use Cephalosporin P = 0.03; 3rd generation cephalosporins P = 0.02
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General Antibiotic Use Greater number used P = 0.02
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Health Status or Disease Severity NE
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Acid Suppression NE
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Hospitalization in an ICU NE
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Age NS
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Miscellaneous
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Results & Comparisons

No Results found.