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Study Title and Description

Predicting Clostridium difficile stool cytotoxin results in hospitalized patients with diarrhea.



Key Questions Addressed
2 Key Question 2 - Description of studies evaluating risk factors for CDI
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5 Key Question 5 - Summary of risk factors for CDI
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Primary Publication Information
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TitleData
Title Predicting Clostridium difficile stool cytotoxin results in hospitalized patients with diarrhea.
Author Katz DA., Bates DW., Rittenberg E., Onderdonk A., Sands K., Barefoot LA., Snydman D.
Country Division of Clinical Decision Making, New England Medical Center and Tufts University School of Medicine, Boston, Mass, USA.
Year 1997
Numbers Pubmed ID: 9034947

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 1 - Description of studies evaluating risk factors for CDI (Table C3)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Type Prospective case series
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Objective Develop predictors for diagnosis of CDAD
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Population 609 adult inpatients tested for C. difficile cytotoxin C. difficile toxin positive (n=49) Mean age 58 years; Female 57% C. difficile toxin negative (n=49) Mean age 58 Female 57%
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Methods Relevant clinical symptoms, signs, and antibiotic exposure were recorded before reporting of assay results. Toxin assay: procedure by Chang Analysis: logistic regression
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Results Potential contributing causes of diarrhea (toxin+ vs. toxin-) Antibiotic use past 30 days: 98% vs. 84% (p=0.009) Cephalosporin use: 73% vs. 49% (p=0.001) Antibiotic use prior to admission/transfer: 51% vs. 32% (p=0.009) Antacid use: 20% vs. 10%, p=0.04. Prior antibiotic use and significant diarrhea were significantly greater in C. difficile toxin positive patients.
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Study Origin United States
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Summary of risk factors for CDI (Table 7)
Arms
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Baseline Characteristics
Question Total Comments
AnswerFollow-up
Specific Antibiotic Use Cephalosporin P = 0.001
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General Antibiotic Use Antibiotic use past 30 days P =0.009; Antibiotic use prior to transfer/ admission P =0.009
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Health Status or Disease Severity NE
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Acid Suppression NE
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Hospitalization in an ICU NE
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Age NE
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Miscellaneous
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Results & Comparisons

No Results found.