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Study Title and Description

Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain.



Key Questions Addressed
3 Key Question 3 - Prevention interventions
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4 Key Question 4 - Studies of Multiple Interventions used together to reduce CDI incidence
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Primary Publication Information
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TitleData
Title Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain.
Author Valiquette L., Cossette B., Garant MP., Diab H., Pépin J.
Country Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. louis.valiquette@usherbrooke.ca
Year 2007
Numbers Pubmed ID: 17683015

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 2 - Prevention interventions (Table 4)
Design Details
Question... Follow Up Answer Follow-up Answer
Country Canada
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Study Design Retrospective time series (before-after)
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Population Hospital patients
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Category of Intervention Multiple Interventions
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Intervention Antimicrobial use, education, isolation, equipment, intensified environmental cleaning
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Outcome CDI incidence
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Findings Nonrestrictive measures to optimize antibiotic usage (leading to decreases in usage) led to a decrease in CDI incidence by 60%
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Quality Issues Retrospective, no concurrent control
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Results & Comparisons

No Results found.

Extraction Form: Key Question 2 - Studies of Multiple Interventions used together to reduce CDI incidence (Tables 5, 6)
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Type of Study Retrospect time series (before–after
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Epidemic or Excessive Incidence? Yes
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CDI incidence Decreased After intervention? Yes
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Results & Comparisons

No Results found.

Quality Dimensions
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Quality Rating
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