Study Title and Description
Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients.
Key Questions Addressed
|8||Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI|
Primary Publication Information
|Title||Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients.|
|Author||Tvede M., Rask-Madsen J.|
|Country||Department of Clinical Microbiology, Rigshospitalet, Statens Seruminstitut, Denmark.|
Pubmed ID: 2566734
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
|Question... Follow Up||Answer||Follow-up Answer|
|Study Focus||Treatment for chronic relapsing C. difficile infection|
|Subject/Study Details||6 patients with chronic relapsing C. difficile infection 1 male and 5 females, age 6-72 years 6 previously treated with vancomycin, 1 treated with cholestyramine and vancomycin and 5 were treated with metronidazole also|
|Interventions||Fecal flora reconstitution: enema of fresh feces from a healthy relative 1 patient Enema of mixture of 10 strains of bacteria: E. coli (1109 & 1108-1), Cl innocuum, Cl ramosum, Bact. Ovatus, Bact. vulgatus, Cl bifermentans, Bact. Thetaiotao-micron, Peptostrepto-coccus productus, Cl bifermentans|
|Clinical Diarrhea Outcomes|
|C. difficile Toxin, C. difficile Culture, or Other||All had stools negative for C. difficile toxin after enema and at 1 yr followup All had stools negative for C. difficile culture after enema and at 1 yr followup|
|Adverse Effects (AE) Harms||Not reported|
Results & Comparisons
No Results found.