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Study Title and Description

Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients.



Key Questions Addressed
8 Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI
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Primary Publication Information
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TitleData
Title Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients.
Author Tvede M., Rask-Madsen J.
Country Department of Clinical Microbiology, Rigshospitalet, Statens Seruminstitut, Denmark.
Year 1989
Numbers Pubmed ID: 2566734
1430 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Focus Treatment for chronic relapsing C. difficile infection
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Subject/Study Details 6 patients with chronic relapsing C. difficile infection 1 male and 5 females, age 6-72 years 6 previously treated with vancomycin, 1 treated with cholestyramine and vancomycin and 5 were treated with metronidazole also
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Interventions Fecal flora reconstitution: enema of fresh feces from a healthy relative 1 patient Enema of mixture of 10 strains of bacteria: E. coli (1109 & 1108-1), Cl innocuum, Cl ramosum, Bact. Ovatus, Bact. vulgatus, Cl bifermentans, Bact. Thetaiotao-micron, Peptostrepto-coccus productus, Cl bifermentans
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Clinical Diarrhea Outcomes
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C. difficile Toxin, C. difficile Culture, or Other All had stools negative for C. difficile toxin after enema and at 1 yr followup All had stools negative for C. difficile culture after enema and at 1 yr followup
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Adverse Effects (AE) Harms Not reported
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Results & Comparisons

No Results found.