Study Title and Description
Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series.
Key Questions Addressed
|8||Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI|
Primary Publication Information
|Title||Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series.|
|Author||MacConnachie AA., Fox R., Kennedy DR., Seaton RA.|
|Country||Brownlee Centre, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK. firstname.lastname@example.org|
Pubmed ID: 19726581
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
|Question... Follow Up||Answer||Follow-up Answer|
|Study Focus||Treatment for recurrent C. difficile infection|
|Subject/Study Details||15 patients with recurrent C. difficile infection which was defined as relapse of loose stool following antibiotic treatment for C. difficile toxin positive stool 14 females, age = 81.5 (68-95) years (median [range]) 11 were inpatients and 4 were newly readmitted after recent discharge; all had several comorbidities and were seriously ill Retrospective chart review|
|Interventions||Fecal flora reconstitution: Stool from healthy relatives administered by nasogastric tube Donors were administered a proton pump inhibitor and oral vancomycin (125 mg 4 tintramusculares/d) up to 12 hours prior to reconstitution|
|Clinical Diarrhea Outcomes||11 (73%) with diarrhea were symptom free of diarrhea at followup and 4 had a relapse of diarrhea Followup was at 16 (4- 24) weeks (median [range])|
|C. difficile Toxin, C. difficile Culture, or Other|
|Adverse Effects (AE) Harms||Reported as none|
Results & Comparisons
No Results found.