Study Title and Description
Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients.
Key Questions Addressed
|8||Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI|
Primary Publication Information
|Title||Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients.|
|Author||Yoon SS., Brandt LJ.|
|Country||Division of Gastroenterology, Department of Medicine, Moses Division of Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.|
Pubmed ID: 20463588
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
|Question... Follow Up||Answer||Follow-up Answer|
|Study Focus||Treatment for recurrent or refractory C. difficile infection|
|Subject/Study Details||12 patients with refractory or recurrent C. difficile infection Defined as having diarrhea and symptoms of cramps and fever and a history of a positive C. difficile toxin assay despite treatment with antibiotics 9 females; age = 66 (30-68) years (mean (range) Retrospective chart review|
|Interventions||Fecal flora reconstitution: Stool from healthy relatives or friend administered via colonoscopy|
|Clinical Diarrhea Outcomes||12 (100%) had cessation of diarrhea and other symptoms within 3-5 days. Follow- up ranged 3 wks to 8 years. No relapse reported.|
|C. difficile Toxin, C. difficile Culture, or Other|
|Adverse Effects (AE) Harms||Reported as none|
Results & Comparisons
No Results found.