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Study Title and Description

Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients.



Key Questions Addressed
8 Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI
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Primary Publication Information
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TitleData
Title Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients.
Author Yoon SS., Brandt LJ.
Country Division of Gastroenterology, Department of Medicine, Moses Division of Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Year 2010
Numbers Pubmed ID: 20463588
1434 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Focus Treatment for recurrent or refractory C. difficile infection
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Subject/Study Details 12 patients with refractory or recurrent C. difficile infection Defined as having diarrhea and symptoms of cramps and fever and a history of a positive C. difficile toxin assay despite treatment with antibiotics 9 females; age = 66 (30-68) years (mean (range) Retrospective chart review
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Interventions Fecal flora reconstitution: Stool from healthy relatives or friend administered via colonoscopy
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Clinical Diarrhea Outcomes 12 (100%) had cessation of diarrhea and other symptoms within 3-5 days. Follow- up ranged 3 wks to 8 years. No relapse reported.
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C. difficile Toxin, C. difficile Culture, or Other
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Adverse Effects (AE) Harms Reported as none
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