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Study Title and Description

Success of self-administered home fecal transplantation for chronic Clostridium difficile infection.



Key Questions Addressed
8 Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI
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Primary Publication Information
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TitleData
Title Success of self-administered home fecal transplantation for chronic Clostridium difficile infection.
Author Silverman MS., Davis I., Pillai DR.
Country Department of Medicine, University of Toronto, Toronto, Ontario, Canada. mikesilverman@rogers.com
Year 2010
Numbers Pubmed ID: 20117243
1435 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Focus Treatment for recurrent C. difficile infection
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Subject/Study Details 7 patients recurrent C. difficile infection defined as with diarrhea after a positive stool toxin test and antibiotic treatment 50% females, age range = 30-88 years; all lived at home after developing C. difficile infection in hospital Patients were treated with a standard antibiotic and probiotic (S. boulardii) up to 24- 48 hours before procedure
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Interventions Fecal flora reconstitution: Donor stools from relatives were infused by low-volume enema by self or family member
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Clinical Diarrhea Outcomes 7 (100%) were free of diarrhea for up to 14 mos. followup
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C. difficile Toxin, C. difficile Culture, or Other
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Adverse Effects (AE) Harms One patient developed infectious irritable bowel symptoms (alternating constipation and diarrhea) but C. difficile toxin test was negative
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