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Study Title and Description

Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain.



Key Questions Addressed
8 Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI
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Primary Publication Information
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TitleData
Title Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain.
Author Seal D., Borriello SP., Barclay F., Welch A., Piper M., Bonnycastle M.
Country -- Not Found --
Year 1987
Numbers Pubmed ID: 3569251
1439 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Focus Treatment
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Subject/Study Details 2 patients, age 88 and 76 years, with C. difficile infection toxin positive, who failed antibiotic treatment.
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Interventions Nontoxigenic strain of C. difficile (M-I) previously shown to protect hamsters One ml was suspended in 50 ml of milk to yield ~10 7 CFU of C. difficile/ml. Given as a single oral dose on 3 successive days.
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Clinical Diarrhea Outcomes Symptoms decreased in 2 patients and C. difficile toxin was (1) eventually 1 patient had a relapse of C. difficile toxin and diarrhea x 2d 17 d after imrprovement
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C. difficile Toxin, C. difficile Culture, or Other
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Adverse Effects (AE) Harms Constipation in 1 patient
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Results & Comparisons

No Results found.