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Study Title and Description

Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: an observational study and review of the literature.



Key Questions Addressed
8 Key Question 8 - Case studies/series and potential harms of nonstandard interventions for CDI
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Primary Publication Information
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TitleData
Title Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: an observational study and review of the literature.
Author Abougergi MS., Broor A., Cui W., Jaar BG.
Country Department of Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA. mabouge1@jhmi.edu
Year 2010
Numbers Pubmed ID: 20063275
1447 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Case studies/series and potential harms of nonstandard interventions for CDI (Table C11)
Design Details
Question... Follow Up Answer Follow-up Answer
Study Focus Treatment
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Subject/Study Details 21 patients with C. difficile colitis defined as C. difficile cytotoxin positive feces + diarrhea + other symptoms of abdominal pain and/or distention or fever +a leukoid reaction (white blood count of 20,000 cell/mm3 or more) + radiographic evidence of colitis or pseudomembranes by colonoscopy or sigmoidoscopy 13 females and 8 males; age = 68 years (13) (mean [SD]) All patients were seriously ill with sepsis and other comorbidities Retrospective chart review
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Interventions intravenous intramuscularmunoglobulin (IVIG) as an adjuvant treatment to standard antibiotics Dose: mode of 250 mg/kg for 1-3 days (dose range = 200- 1,250 mg/kg)
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Clinical Diarrhea Outcomes 9 patients (43%) survived with resolution of clinical symptoms of C. difficile colitis
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Adverse Effects (AE) Harms Pulmonary edema in 1 patient
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Results & Comparisons

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