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Study Title and Description

The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients.



Key Questions Addressed
9 Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI
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Primary Publication Information
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TitleData
Title The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients.
Author Lewis SJ., Potts LF., Barry RE.
Country Department of Medicine, Bristol Royal Infirmary, UK.
Year 1998
Numbers Pubmed ID: 9570649
1458 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
Design Details
Question... Follow Up Answer Follow-up Answer
Country / Study Design United Kingdom Randomized controlled trial
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Sample 72 Hospitalized elderly (•65 years) patients started on antibiotics Mean age (range): 74 (70-85) years Gender not reported ("no difference between sex")
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Prevention of initial or recurrent Clostridium difficile infection? Primary Prevention of Initial Clostridium difficile infection
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Intervention/Comparison and Method Probiotic: S. boulardii (113 mg) (Ultra-Levure, Biocodex, Montrouge, FR) 2x/day (n=33) Placebo (undefined) 2x/day (n=36) Stool sample sent to lab every 4th day or if diarrhea (•3 loose stools in 24 hours) to test for CD toxin
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C. difficile Diarrhea (Diarrhea and CD Toxin +) Overall incidence of Clostridium difficile infection: 4 patients had diarrhea stools that were CD toxin+ (not reported by treatment arm) No statistically significant difference in diarrhea stools with + CD toxin between probiotic and placebo (data and percents not reported)
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Later Recurrence of CD Diarrhea
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CD Toxin+ CD toxin only Probiotic: 5/33 (15%) Placebo 3/36 (8%) No statistical testing done
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Notes of Study Quality and Side Effects Allocation concealment: adequate (pharmacy- controlled) Blinding: probably double, nursing staff blinded to treatment assignment Intention-to-treat analysis: no, 3 excluded Withdrawals and dropouts adequately described: yes
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Results & Comparisons

No Results found.