Study Title and Description
The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients.
Key Questions Addressed
|9||Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI|
Primary Publication Information
|Title||The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients.|
|Author||Lewis SJ., Potts LF., Barry RE.|
|Country||Department of Medicine, Bristol Royal Infirmary, UK.|
Pubmed ID: 9570649
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
|Question... Follow Up||Answer||Follow-up Answer|
|Country / Study Design||United Kingdom Randomized controlled trial|
|Sample||72 Hospitalized elderly (65 years) patients started on antibiotics Mean age (range): 74 (70-85) years Gender not reported ("no difference between sex")|
|Prevention of initial or recurrent Clostridium difficile infection?||Primary Prevention of Initial Clostridium difficile infection|
|Intervention/Comparison and Method||Probiotic: S. boulardii (113 mg) (Ultra-Levure, Biocodex, Montrouge, FR) 2x/day (n=33) Placebo (undefined) 2x/day (n=36) Stool sample sent to lab every 4th day or if diarrhea (3 loose stools in 24 hours) to test for CD toxin|
|C. difficile Diarrhea (Diarrhea and CD Toxin +)||Overall incidence of Clostridium difficile infection: 4 patients had diarrhea stools that were CD toxin+ (not reported by treatment arm) No statistically significant difference in diarrhea stools with + CD toxin between probiotic and placebo (data and percents not reported)|
|Later Recurrence of CD Diarrhea|
|CD Toxin+||CD toxin only Probiotic: 5/33 (15%) Placebo 3/36 (8%) No statistical testing done|
|Notes of Study Quality and Side Effects||Allocation concealment: adequate (pharmacy- controlled) Blinding: probably double, nursing staff blinded to treatment assignment Intention-to-treat analysis: no, 3 excluded Withdrawals and dropouts adequately described: yes|
Results & Comparisons
No Results found.