Study Title and Description
Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea.
Key Questions Addressed
|9||Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI|
Primary Publication Information
|Title||Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea.|
|Author||Plummer S., Weaver MA., Harris JC., Dee P., Hunter J.|
|Country||Cultech Ltd., York Chambers, York Street, Swansea, SA1 3NJ, United Kingdom. email@example.com|
Pubmed ID: 15179608
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
|Question... Follow Up||Answer||Follow-up Answer|
|Country / Study Design||United Kingdom Randomized controlled trial|
|Sample||150 elderly hospitalized patients started on antibiotics 138 (92%) completed study Age and gender not reported|
|Prevention of initial or recurrent Clostridium difficile infection?||Primary Prevention of Initial Clostridium difficile infection|
|Intervention/Comparison and Method||Probiotic: Lactobacillus acidophilus and Bifidobacterium bifidum, 2 x 1010 cfu in 1 capsule/d (Cultech, Saansea) for at least 20 of antibiotic therapy (n=69) Placebo (n=69) Start therapy within 36 hours of antibiotics, probiotic = 1.12 days after antibiotics placebo = 1.10 day Stools were cultured for C. difficile, then if culture +, CD toxins A and B were tested - at start of study - if diarrhea - after antibiotics completed during hospitalization or discharge|
|C. difficile Diarrhea (Diarrhea and CD Toxin +)||CD diarrhea, 1st testing, during diarrhea and antibiotic tx in hospital: Probiotic: 2/69 (3%) Placebo: 5/69 (7%), no statistical testing reported, Fisher’s Exact test performed by reviewers p=0.44 Proportion developing diarrhea positive for CD toxins was 4.35% lower in probiotic group (95% CI of -0.132 to 0.038). CD diarrhea, 2nd testing of same patients after antibiotics completed or at discharge: Probiotic: 2/69 (3%) Placebo: 6/69 (9%)|
|Later Recurrence of CD Diarrhea|
|Notes of Study Quality and Side Effects||Allocation concealment: not defined Blinding: double Intention-to-treat analysis: no Withdrawals and dropouts adequately described: no Notes: Diarrhea is undefined Study participation stopped if on antibiotics >20 days|
Results & Comparisons
No Results found.