Study Title and Description
Failure of dietary oligofructose to prevent antibiotic-associated diarrhoea.
Key Questions Addressed
|9||Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI|
Primary Publication Information
|Title||Failure of dietary oligofructose to prevent antibiotic-associated diarrhoea.|
|Author||Lewis S., Burmeister S., Cohen S., Brazier J., Awasthi A.|
|Country||Department of Medicine, Addenbrooke's Hospital, Cambridge, UK. email@example.com|
Pubmed ID: 15709999
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
|Question... Follow Up||Answer||Follow-up Answer|
|Country / Study Design||United Kingdom Randomized controlled trial|
|Sample||450 hospital patients 65 years prescribed a broad spectrum antibiotic within past 24 hours 15 (3.3%) patients withdrew or were withdrawn from study N=435 who finished Mean age (range): 77 (70-84) years Gender: Male 49%|
|Prevention of initial or recurrent Clostridium difficile infection?||Primary Prevention of Initial Clostridium difficile infection|
|Intervention/Comparison and Method||Prebiotic: Oligofructose (12 g/d) (n=215) Placebo (sucrose 12 g/day) (n=220) Taken during antibiotics + 7 days after Follow up for additional 7 days C difficile toxin was measured if diarrhea (1-2 loose stools/day)|
|C. difficile Diarrhea (Diarrhea and CD Toxin +)||54 (12%) patients were culture-positive for C. difficile on study entry. Prebiotic: 19/213 (9%) Placebo: 21/220 (9.5%), no statistical testing reported, Fisher’s Exact test performed by reviewers p=0.87|
|Later Recurrence of CD Diarrhea|
|Notes of Study Quality and Side Effects||Allocation concealment: Unclear Blinding: double Intention-to-treat analysis: no Withdrawals and dropouts adequately described: yes Notes: Subjects were withdrawn from study if they experienced significant diarrhea (>3 stools/day) Stated intent to treat but some % are for N=433 not 435 or 450 who enrolled No increase in bloating, stool form or interval between stools by prebiotic|
Results & Comparisons
No Results found.