Study Title and Description
Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study.
Key Questions Addressed
|9||Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI|
Primary Publication Information
|Title||Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study.|
|Author||Can M., Beşirbellioglu BA., Avci IY., Beker CM., Pahsa A.|
|Country||Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey.|
Pubmed ID: 16572062
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
|Question... Follow Up||Answer||Follow-up Answer|
|Country / Study Design||Turkey Randomized controlled trial|
|Sample||151 adult inpatients between 25-50 years who had chemotherapy and antibiotics Gender: Male 95%|
|Prevention of initial or recurrent Clostridium difficile infection?||Primary Prevention of Initial Clostridium difficile infection|
|Intervention/Comparison and Method||Probiotic: S. boulardii + antibiotics (? lactam) (n=73) Placebo + antibiotics(n=78) 2x/day started 48 hours or less after antibiotic therapy started for duration of antibiotic tx CD toxin A tested in those with diarrhea|
|C. difficile Diarrhea (Diarrhea and CD Toxin +)||Overall incidence of Clostridium difficile infection: 8 patients had diarrhea, only two CD toxin + (both in the placebo group Probiotic: 0/73 (0%) Placebo: 2/78 (2.6%) Fisher’s Exact test performed by reviewers p=0.50|
|Later Recurrence of CD Diarrhea|
|Notes of Study Quality and Side Effects||Allocation concealment: not defined Blinding: double Intention-to-treat analysis: yes Withdrawals and dropouts adequately described: none reported Notes: Duration of probiotic may have been variable Diarrhea is undefined|
Results & Comparisons
No Results found.