Advanced Search

Study Preview



Study Title and Description

Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study.



Key Questions Addressed
9 Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study.
Author Can M., Beşirbellioglu BA., Avci IY., Beker CM., Pahsa A.
Country Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey.
Year 2006
Numbers Pubmed ID: 16572062
1462 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
Design Details
Question... Follow Up Answer Follow-up Answer
Country / Study Design Turkey Randomized controlled trial
  • Comments Comments (
    0
    ) |
Sample 151 adult inpatients between 25-50 years who had chemotherapy and antibiotics Gender: Male 95%
  • Comments Comments (
    0
    ) |
Prevention of initial or recurrent Clostridium difficile infection? Primary Prevention of Initial Clostridium difficile infection
  • Comments Comments (
    0
    ) |
Intervention/Comparison and Method Probiotic: S. boulardii + antibiotics (? lactam) (n=73) Placebo + antibiotics(n=78) 2x/day started 48 hours or less after antibiotic therapy started for duration of antibiotic tx CD toxin A tested in those with diarrhea
  • Comments Comments (
    0
    ) |
C. difficile Diarrhea (Diarrhea and CD Toxin +) Overall incidence of Clostridium difficile infection: 8 patients had diarrhea, only two CD toxin + (both in the placebo group Probiotic: 0/73 (0%) Placebo: 2/78 (2.6%) Fisher’s Exact test performed by reviewers p=0.50
  • Comments Comments (
    0
    ) |
Later Recurrence of CD Diarrhea
  • Comments Comments (
    0
    ) |
CD Toxin+
  • Comments Comments (
    0
    ) |
Notes of Study Quality and Side Effects Allocation concealment: not defined Blinding: double Intention-to-treat analysis: yes Withdrawals and dropouts adequately described: none reported Notes: Duration of probiotic may have been variable Diarrhea is undefined
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.