Study Title and Description
Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study.
Key Questions Addressed
|9||Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI|
Primary Publication Information
|Title||Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study.|
|Author||Lewis S., Burmeister S., Brazier J.|
|Country||Department of Medicine, Derriford Hospital, Plymouth, UK email@example.com|
Pubmed ID: 15880313
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
|Question... Follow Up||Answer||Follow-up Answer|
|Country / Study Design||Randomized controlled trial|
|Sample||142 consecutive elderly (65 years) in patients with Clostridium difficile infection and treated by their physician with metronidazole or vancomycin for 10 days (if treatment failure (diarrhea and CD toxin A and B) or intolerance with metronidazole). Mean age: 75 years Gender: Male 58%|
|Prevention of initial or recurrent Clostridium difficile infection?||Prevention of Recurrent Clostridium difficile infection|
|Intervention/Comparison and Method||Prebiotic: Oligofructose (12 g/d) (n=72) Placebo (sucrose 12 g/day) (n=70) Taken as soon as possible after dx of CD diarrhea and + 30 days after Clostridium difficile infection diarrhea = 3 loose stools in 1 day and + CD toxin|
|C. difficile Diarrhea (Diarrhea and CD Toxin +)|
|Later Recurrence of CD Diarrhea||Relapse of diarrhea (CD was not retested) Prebiotic: 6/72 (8.3%) Placebo: 24/70 (34.3%), p<0.0001|
|Notes of Study Quality and Side Effects||Allocation concealment: Not defined Blinding: single Intention-to-treat analysis: no, 1 was lost to followup and 8 never resolved diarrhea to be able to relapse and were excluded Withdrawals and dropouts adequately described: yes Notes: CD was not measured at diarrhea recurrence|
Results & Comparisons
No Results found.