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Study Title and Description

Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study.



Key Questions Addressed
9 Key Question 9 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI
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Primary Publication Information
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TitleData
Title Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study.
Author Lewis S., Burmeister S., Brazier J.
Country Department of Medicine, Derriford Hospital, Plymouth, UK sjl@dircon.co.uk
Year 2005
Numbers Pubmed ID: 15880313
1485 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 4 - Probiotic or prebiotic interventions for prevention of initial and recurrent CDI (Table 20)
Design Details
Question... Follow Up Answer Follow-up Answer
Country / Study Design Randomized controlled trial
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Sample 142 consecutive elderly (•65 years) in patients with Clostridium difficile infection and treated by their physician with metronidazole or vancomycin for 10 days (if treatment failure (diarrhea and CD toxin A and B) or intolerance with metronidazole). Mean age: 75 years Gender: Male 58%
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Prevention of initial or recurrent Clostridium difficile infection? Prevention of Recurrent Clostridium difficile infection
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Intervention/Comparison and Method Prebiotic: Oligofructose (12 g/d) (n=72) Placebo (sucrose 12 g/day) (n=70) Taken as soon as possible after dx of CD diarrhea and + 30 days after Clostridium difficile infection diarrhea = 3 loose stools in 1 day and + CD toxin
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C. difficile Diarrhea (Diarrhea and CD Toxin +)
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Later Recurrence of CD Diarrhea Relapse of diarrhea (CD was not retested) Prebiotic: 6/72 (8.3%) Placebo: 24/70 (34.3%), p<0.0001
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CD Toxin+
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Notes of Study Quality and Side Effects Allocation concealment: Not defined Blinding: single Intention-to-treat analysis: no, 1 was lost to followup and 8 never resolved diarrhea to be able to relapse and were excluded Withdrawals and dropouts adequately described: yes Notes: CD was not measured at diarrhea recurrence
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Results & Comparisons

No Results found.