Study Title and Description
Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review.
Key Questions Addressed
|10||Key Question 10 - Reviews and Meta-analyses|
Primary Publication Information
|Title||Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review.|
|Author||Planche T., Aghaizu A., Holliman R., Riley P., Poloniecki J., Breathnach A., Krishna S.|
|Country||Department of Medical Microbiology, St George's Hospital, London, UK.|
Pubmed ID: 18977696
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Reviews and Meta-analyses (Table C12)
No arms have been defined in this extraction form.
|Question... Follow Up||Answer||Follow-up Answer|
|Focus of Review||Diagnosis|
|Title/Question Patient Population||Diagnosis of Clostridium difficile infection by toxin detection kits. Toxins A & B All inpatients|
|# of Studies Patient N||18 trials N=62 to 2,891 Meta-analysis|
|Comparators||ELISA (Meridian, Techlab), Rapid antigen capture (Techlab), Rapid CI (Remel), EIA (BioMerieus) Rapid EIA (Meridian) compared to cell culture w/neutralisable toxin|
|Outcomes Followup||Sensitivity, specificity|
|Results||No test met acceptable criteria (sensitivity IQR >90%, and false positivity below 3%). No difference in diagnostic performance of commercially available tests. Most had higher specificity than sensitivity. Differences between tests likely due to assay threshold cutoff.|
No baseline characteristics have been defined for this extraction form.
Results & Comparisons
No Results found.
|Arm or Total||Title||Description||Comments|
No quality dimensions were specified.
No quality rating data was found.