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Study Title and Description

Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review.



Key Questions Addressed
10 Key Question 10 - Reviews and Meta-analyses
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Primary Publication Information
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TitleData
Title Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review.
Author Planche T., Aghaizu A., Holliman R., Riley P., Poloniecki J., Breathnach A., Krishna S.
Country Department of Medical Microbiology, St George's Hospital, London, UK.
Year 2008
Numbers Pubmed ID: 18977696
1489 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Reviews and Meta-analyses (Table C12)
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Design Details
Question... Follow Up Answer Follow-up Answer
Focus of Review Diagnosis
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Title/Question Patient Population Diagnosis of Clostridium difficile infection by toxin detection kits. Toxins A & B All inpatients
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# of Studies Patient N 18 trials N=62 to 2,891 Meta-analysis
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Comparators ELISA (Meridian, Techlab), Rapid antigen capture (Techlab), Rapid CI (Remel), EIA (BioMerieus) Rapid EIA (Meridian) compared to cell culture w/neutralisable toxin
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Outcomes Followup Sensitivity, specificity
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Results No test met acceptable criteria (sensitivity IQR >90%, and false positivity below 3%). No difference in diagnostic performance of commercially available tests. Most had higher specificity than sensitivity. Differences between tests likely due to assay threshold cutoff.
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Results & Comparisons

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Adverse Events
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