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Study Title and Description

Systematic review of the risk of enteric infection in patients taking acid suppression.



Key Questions Addressed
10 Key Question 10 - Reviews and Meta-analyses
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Primary Publication Information
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TitleData
Title Systematic review of the risk of enteric infection in patients taking acid suppression.
Author Leonard J., Marshall JK., Moayyedi P.
Country Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
Year 2007
Numbers Pubmed ID: 17509031
1491 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Reviews and Meta-analyses (Table C12)
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Focus of Review Prevention
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Title/Question Patient Population Risk of enteric infection in patients taking acid suppression Primarily inpatient
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# of Studies Patient N 25 observational studies N=1,382 Meta-analysis
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Comparators Use of PPI or H2RA versus multiple control group types
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Outcomes Followup Presence of enteric infection
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Results PPI: OR 2.05 (1.47-2.85); H2RA: OR 1.48 (1.06 - 2.06); Overall: OR 1.95 (1.48- 2.58). Significant heterogeneity between studies. ORs for other enteric infections were even greater. Index cases?
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Baseline Characteristics
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Results & Comparisons

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Adverse Events
Arm or Total Title Description Comments

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