Study Title and Description
Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.
Key Questions Addressed
|10||Key Question 10 - Reviews and Meta-analyses|
Primary Publication Information
|Title||Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.|
|Country||Department of Health Services Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98101, USA.|
Pubmed ID: 16635227
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Reviews and Meta-analyses (Table C12)
No arms have been defined in this extraction form.
|Question... Follow Up||Answer||Follow-up Answer|
|Focus of Review||Treatment|
|Title/Question Patient Population||Probiotics for prevention of antibiotic associated diarrhea and treatment of C. difficile disease Primarily inpatient|
|# of Studies Patient N||31 trials; ADD 25, CDI 6 N = 3,164 Meta-analysis|
|Comparators||Use of probiotics, multiple forms, versus placebo|
|Outcomes Followup||New diarrhea episode associated with positive culture or toxin assay within 1 month of antibiotic exposure|
|Results||ADD prevention: RR 0.43 (0.31-0.58). CDI treatment: RR 0.59 (0.41-0.85) Most benefit in CDI seen in treatment of patients with recurrent CDI, S. boulardii was effective agent.|
No baseline characteristics have been defined for this extraction form.
Results & Comparisons
No Results found.
|Arm or Total||Title||Description||Comments|
No quality dimensions were specified.
No quality rating data was found.