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Study Title and Description

Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.



Key Questions Addressed
10 Key Question 10 - Reviews and Meta-analyses
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Primary Publication Information
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TitleData
Title Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.
Author McFarland LV.
Country Department of Health Services Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98101, USA.
Year 2006
Numbers Pubmed ID: 16635227
1497 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Reviews and Meta-analyses (Table C12)
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Focus of Review Treatment
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Title/Question Patient Population Probiotics for prevention of antibiotic associated diarrhea and treatment of C. difficile disease Primarily inpatient
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# of Studies Patient N 31 trials; ADD 25, CDI 6 N = 3,164 Meta-analysis
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Comparators Use of probiotics, multiple forms, versus placebo
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Outcomes Followup New diarrhea episode associated with positive culture or toxin assay within 1 month of antibiotic exposure
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Results ADD prevention: RR 0.43 (0.31-0.58). CDI treatment: RR 0.59 (0.41-0.85) Most benefit in CDI seen in treatment of patients with recurrent CDI, S. boulardii was effective agent.
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Results & Comparisons

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Adverse Events
Arm or Total Title Description Comments

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