Study Title and Description
Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review.
Key Questions Addressed
|10||Key Question 10 - Reviews and Meta-analyses|
Primary Publication Information
|Title||Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review.|
|Author||Dendukuri N., Costa V., McGregor M., Brophy JM.|
|Country||Technology Assessment Unit, McGill University Health Centre, McGill University, Montréal, Que. firstname.lastname@example.org|
Pubmed ID: 16027434
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Reviews and Meta-analyses (Table C12)
No arms have been defined in this extraction form.
|Question... Follow Up||Answer||Follow-up Answer|
|Focus of Review||Treatment|
|Title/Question Patient Population||Probiotic therapy for the prevention and treatment of C.difficile-associated diarrhea Adult inpatients|
|# of Studies Patient N||1 prevention trial, 3 treatment|
|Comparators||Probiotics versus placebo; L. acidophilus, L. plantarum, L. GG, Bifidocaterium bifidum, S. boulardii (5)|
|Outcomes Followup||Prevention of AAD 11 days to 8 weeks|
|Results||No differences between groups for prevention. Only one found improvement for treatment. Subgroup analysis suggests limited to recurrent CDI. Dose was same as used in pediatric studies with positive results. Variability in CDI definition.|
No baseline characteristics have been defined for this extraction form.
Results & Comparisons
No Results found.
|Arm or Total||Title||Description||Comments|
No quality dimensions were specified.
No quality rating data was found.