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Study Title and Description

Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review.



Key Questions Addressed
10 Key Question 10 - Reviews and Meta-analyses
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Primary Publication Information
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TitleData
Title Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review.
Author Dendukuri N., Costa V., McGregor M., Brophy JM.
Country Technology Assessment Unit, McGill University Health Centre, McGill University, Montréal, Que. nandini.dendukuri@mcgill.ca
Year 2005
Numbers Pubmed ID: 16027434
1498 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Reviews and Meta-analyses (Table C12)
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Focus of Review Treatment
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Title/Question Patient Population Probiotic therapy for the prevention and treatment of C.difficile-associated diarrhea Adult inpatients
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# of Studies Patient N 1 prevention trial, 3 treatment
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Comparators Probiotics versus placebo; L. acidophilus, L. plantarum, L. GG, Bifidocaterium bifidum, S. boulardii (5)
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Outcomes Followup Prevention of AAD 11 days to 8 weeks
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Results No differences between groups for prevention. Only one found improvement for treatment. Subgroup analysis suggests limited to recurrent CDI. Dose was same as used in pediatric studies with positive results. Variability in CDI definition.
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Baseline Characteristics
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Results & Comparisons

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Adverse Events
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