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Study Title and Description

Review article: treatment of Clostridium difficile infection.



Key Questions Addressed
10 Key Question 10 - Reviews and Meta-analyses
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Primary Publication Information
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TitleData
Title Review article: treatment of Clostridium difficile infection.
Author Zimmerman MJ., Bak A., Sutherland LR.
Country Gastroenterology Unit, Royal Perth Hospital, WA, Australia.
Year 1997
Numbers Pubmed ID: 9663822
1500 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Reviews and Meta-analyses (Table C12)
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Focus of Review Treatment
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Title/Question Patient Population Antibiotic treatment of C. difficile infection
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# of Studies Patient N 9 trials Meta-analysis
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Comparators 5 antibiotics, 2 placebo controlled
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Outcomes Followup Clinical resolution of diarrhea, relapse, negative test for toxin Average 1 month
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Results Colestipol no better than placebo, but of other 4, no significant differences between types or doses of antibiotics for clinical resolution. Teicoplanin better than fusidic acid for relapse. Unclear if higher dose of teicoplanin reduces relapse.
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Baseline Characteristics
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Results & Comparisons

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Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
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