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Project: Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review

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Title Created by Key Questions Addressed Form Notes
Comparative Studies Bryant Smith 1
Observational Studies Bryant Smith 2

Associated Studies (each link opens a new tab)

Title Author Year
Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. Tatsuno I., Saito Y., Kudou K., Ootake J. 2013
A long-term seal- and cod-liver-oil supplementation in hypercholesterolemic subjects. zz_Brox J., Olaussen K., Osterud B., Elvevoll EO., Bjørnstad E., Brattebøg G., Iversen H. 2001
Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome--LIPGENE: a European randomized dietary intervention study. Tierney AC., McMonagle J., Shaw DI., Gulseth HL., Helal O., Saris WH., Paniagua JA., Gołąbek-Leszczyñska I., Defoort C., Williams CM., Karsltröm B., Vessby B., Dembinska-Kiec A., López-Miranda J., Blaak EE., Drevon CA., Gibney MJ., Lovegrove JA., Roche HM. 2011
Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults. zz AlSaleh A., Maniou Z., Lewis FJ., Hall WL., Sanders TA., O'Dell SD. 2014
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Yokoyama M., Origasa H., Matsuzaki M., Matsuzawa Y., Saito Y., Ishikawa Y., Oikawa S., Sasaki J., Hishida H., Itakura H., Kita T., Kitabatake A., Nakaya N., Sakata T., Shimada K., Shirato K. 2007
A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial). Maki KC., Orloff DG., Nicholls SJ., Dunbar RL., Roth EM., Curcio D., Johnson J., Kling D., Davidson MH. 2013
Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. Sanders TA., Hall WL., Maniou Z., Lewis F., Seed PT., Chowienczyk PJ. 2011
Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women. Carrepeiro MM., Rogero MM., Bertolami MC., Botelho PB., Castro N., Castro IA. 2011
Atorvastatin in Factorial with Omega-3 EE90 Risk Reduction in Diabetes (AFORRD): a randomised controlled trial. Holman RR., Paul S., Farmer A., Tucker L., Stratton IM., Neil HA. 2009
Baseline lipoprotein lipids and low-density lipoprotein cholesterol response to prescription omega-3 acid ethyl ester added to Simvastatin therapy. Maki KC., Dicklin MR., Davidson MH., Doyle RT., Ballantyne CM. 2010
Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Ballantyne CM., Bays HE., Kastelein JJ., Stein E., Isaacsohn JL., Braeckman RA., Soni PN. 2012
Effects of varying dietary fat, fish, and fish oils on blood lipids in a randomized controlled trial in men at risk of heart disease. zz_Mori TA., Vandongen R., Beilin LJ., Burke V., Morris J., Ritchie J. 1994
Effects of stable fish oil and simvastatin on plasma lipoproteins in patients with hyperlipidemia. Liu M, Agneta Wallmon, Rolf Wallin, Tom Saldeen 2003
Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(registered trademark) REVEAL Trial zz_Shaikh NAY, J. Shaikh and S. Rowe and W. Laidlaw and M. Cockerline and C. Ali and A. Holub and B. Jackowski and G. 2014
Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Rasmussen BM., Vessby B., Uusitupa M., Berglund L., Pedersen E., Riccardi G., Rivellese AA., Tapsell L., Hermansen K. 2006
APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults. Carvalho-Wells AL., Jackson KG., Lockyer S., Lovegrove JA., Minihane AM. 2012
Impact of atorvastatin plus n-3 PUFA on metabolic, inflammatory and coagulative parameters in metabolic syndrome without and with type 2 diabetes mellitus zz_REJECT_Avellone G, Valentina Guarnotta, Vincenzo Di Garbo, Giovanni Abruzzese, Domenico Campisi, Antonio Pinto, Giuseppina Pizzo, Giuseppe Licata 2009
Complementary effects of multivitamin and omega-3 fatty acid supplementation on indices of cardiovascular health in individuals with elevated homocysteine. Earnest CP., Kupper JS., Thompson AM., Guo W., Church T. 2012
Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Burr ML., Fehily AM., Gilbert JF., Rogers S., Holliday RM., Sweetnam PM., Elwood PC., Deadman NM. 1989
N-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia. Vecka M., Dušejovská M., Stankova B., Zeman M., Vavrova L., Kodydkova J., Slaby A., Zak A. 2012
Potent antihypertensive action of dietary flaxseed in hypertensive patients. Rodriguez-Leyva D., Weighell W., Edel AL., LaVallee R., Dibrov E., Pinneker R., Maddaford TG., Ramjiawan B., Aliani M., Guzman R., Pierce GN. 2013
Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. Galan P., Kesse-Guyot E., Czernichow S., Briancon S., Blacher J., Hercberg S. 2010
Comparison of the effects of simultaneous administration of vitamin C and omega-3 fatty acids on lipoproteins, apo A-I, apo B, and malondialdehyde in hyperlipidemic patients. Shidfar F., Keshavarz A., Jallali M., Miri R., Eshraghian M. 2003
Absence of prophylactic effect of linolenic acid in patients with coronary heart-disease. zz_REJECT_Borchgrevink CF., Skaga E., Berg KJ., Skjaeggestad O. 1966
Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers. zz_Vega-López S., Kaul N., Devaraj S., Cai RY., German B., Jialal I. 2004
Lack of benefit of dietary advice to men with angina: results of a controlled trial. Burr ML., Ashfield-Watt PA., Dunstan FD., Fehily AM., Breay P., Ashton T., Zotos PC., Haboubi NA., Elwood PC. 2003
Can foods with added soya-protein or fish-oil reduce risk factors for coronary disease? A factorial randomised controlled trial. Harrison RA., Sagara M., Rajpura A., Armitage L., Birt N., Birt CA., Yamori Y. 2004
n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. Bosch J., Gerstein HC., Dagenais GR., Díaz R., Dyal L., Jung H., Maggiono AP., Probstfield J., Ramachandran A., Riddle MC., Rydén LE., Yusuf S. 2012
Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Marchioli R., Barzi F., Bomba E., Chieffo C., Di Gregorio D., Di Mascio R., Franzosi MG., Geraci E., Levantesi G., Maggioni AP., Mantini L., Marfisi RM., Mastrogiuseppe G., Mininni N., Nicolosi GL., Santini M., Schweiger C., Tavazzi L., Tognoni G., Tucci C., Valagussa F. 2002
OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Rauch B., Schiele R., Schneider S., Diller F., Victor N., Gohlke H., Gottwik M., Steinbeck G., Del Castillo U., Sack R., Worth H., Katus H., Spitzer W., Sabin G., Senges J. 2010
Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. Baxheinrich A., Stratmann B., Lee-Barkey YH., Tschoepe D., Wahrburg U. 2012
Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Ebrahimi M., Ghayour-Mobarhan M., Rezaiean S., Hoseini M., Parizade SM., Farhoudi F., Hosseininezhad SJ., Tavallaei S., Vejdani A., Azimi-Nezhad M., Shakeri MT., Rad MA., Mobarra N., Kazemi-Bajestani SM., Ferns GA. 2009
Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Tavazzi L., Maggioni AP., Marchioli R., Barlera S., Franzosi MG., Latini R., Lucci D., Nicolosi GL., Porcu M., Tognoni G. 2008
Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) trial. Macchia A., Grancelli H., Varini S., Nul D., Laffaye N., Mariani J., Ferrante D., Badra R., Figal J., Ramos S., Tognoni G., Doval HC. 2013
n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: a prospective, randomized study. Nodari S., Triggiani M., Campia U., Manerba A., Milesi G., Cesana BM., Gheorghiade M., Dei Cas L. 2011
Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. Raitt MH., Connor WE., Morris C., Kron J., Halperin B., Chugh SS., McClelland J., Cook J., MacMurdy K., Swenson R., Connor SL., Gerhard G., Kraemer DF., Oseran D., Marchant C., Calhoun D., Shnider R., McAnulty J. 2005
Fish oil and neurovascular control in humans. Carter JR., Schwartz CE., Yang H., Joyner MJ. 2012
Reduction of blood pressure and plasma triglycerides by omega-3 fatty acids in treated hypertensives. Lungershausen YK., Abbey M., Nestel PJ., Howe PR. 1994
Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Leaf A., Albert CM., Josephson M., Steinhaus D., Kluger J., Kang JX., Cox B., Zhang H., Schoenfeld D. 2005
n-3 fatty acids and cardiovascular events after myocardial infarction. Kromhout D., Giltay EJ., Geleijnse JM. 2010
Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Caslake MJ., Miles EA., Kofler BM., Lietz G., Curtis P., Armah CK., Kimber AC., Grew JP., Farrell L., Stannard J., Napper FL., Sala-Vila A., West AL., Mathers JC., Packard C., Williams CM., Calder PC., Minihane AM. 2008
n-3 fatty acids in patients with multiple cardiovascular risk factors. Roncaglioni MC., Tombesi M., Avanzini F., Barlera S., Caimi V., Longoni P., Marzona I., Milani V., Silletta MG., Tognoni G., Marchioli R. 2013
Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Olano-Martin E., Anil E., Caslake MJ., Packard CJ., Bedford D., Stewart G., Peiris D., Williams CM., Minihane AM. 2010
DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial. Jones PJ., Senanayake VK., Pu S., Jenkins DJ., Connelly PW., Lamarche B., Couture P., Charest A., Baril-Gravel L., West SG., Liu X., Fleming JA., McCrea CE., Kris-Etherton PM. 2014
The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. von Schacky C., Angerer P., Kothny W., Theisen K., Mudra H. 1999
Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Grimsgaard S., Bønaa KH., Hansen JB., Myhre ES. 1998
Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Eritsland J., Arnesen H., Grønseth K., Fjeld NB., Abdelnoor M. 1996
Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. Sacks FM., Stone PH., Gibson CM., Silverman DI., Rosner B., Pasternak RC. 1995
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. zz_REJECT_de Lorgeril M., Renaud S., Mamelle N., Salen P., Martin JL., Monjaud I., Guidollet J., Touboul P., Delaye J. 1994
Investigation of the effects of a high fish diet on inflammatory cytokines, blood pressure, and lipids in healthy older Australians. Grieger JA., Miller MD., Cobiac L. 2014
Alimentary habits, physical activity, and Framingham global risk score in metabolic syndrome. Soares TS., Piovesan CH., Gustavo Ada S., Macagnan FE., Bodanese LC., Feoli AM. 2014
Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. Brouwer IA., Zock PL., Camm AJ., Böcker D., Hauer RN., Wever EF., Dullemeijer C., Ronden JE., Katan MB., Lubinski A., Buschler H., Schouten EG. 2006
Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. Kastelein JJ., Maki KC., Susekov A., Ezhov M., Nordestgaard BG., Machielse BN., Kling D., Davidson MH. 2014
A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk. Einvik G., Klemsdal TO., Sandvik L., Hjerkinn EM. 2010
N-3 fatty acids do not lead to an increased diabetic risk in patients with hyperlipidemia and abnormal glucose tolerance. Italian Fish Oil Multicenter Study. Sirtori CR., Paoletti R., Mancini M., Crepaldi G., Manzato E., Rivellese A., Pamparana F., Stragliotto E. 1997
One-year treatment with ethyl esters of n-3 fatty acids in patients with hypertriglyceridemia and glucose intolerance: reduced triglyceridemia, total cholesterol and increased HDL-C without glycemic alterations. zz_Sirtori CR., Crepaldi G., Manzato E., Mancini M., Rivellese A., Paoletti R., Pazzucconi F., Pamparana F., Stragliotto E. 1998
Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men. Damsgaard CT., Frøkiaer H., Andersen AD., Lauritzen L. 2008
Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. Sacks FM., Hebert P., Appel LJ., Borhani NO., Applegate WB., Cohen JD., Cutler JA., Kirchner KA., Kuller LH., Roth KJ. 1994
Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. Nodari S., Triggiani M., Campia U., Manerba A., Milesi G., Cesana BM., Gheorghiade M., Dei Cas L. 2011
Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia. Oh PC., Koh KK., Sakuma I., Lim S., Lee Y., Lee S., Lee K., Han SH., Shin EK. 2014
The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. A controlled clinical trial. zz_REJECT_Leren P. 1966
Fish, n-3 fatty acids, and cardiovascular diseases in women of reproductive age: a prospective study in a large national cohort. Strøm M., Halldorsson TI., Mortensen EL., Torp-Pedersen C., Olsen SF. 2012
Fish intake and risks of total and cause-specific mortality in 2 population-based cohort studies of 134,296 men and women. Takata Y., Zhang X., Li H., Gao YT., Yang G., Gao J., Cai H., Xiang YB., Zheng W., Shu XO. 2013
A controlled trial of the effect of linolenic acid on incidence of coronary heart disease. The Norwegian vegetable oil experiment of 1965-66. Natvig H., Borchgrevink CF., Dedichen J., Owren PA., Schiotz EH., Westlund K. 1968
Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. Joensen AM., Schmidt EB., Dethlefsen C., Johnsen SP., Tjønneland A., Rasmussen LH., Overvad K. 2010
Effects of long chain omega-3 fatty acids on metalloproteinases and their inhibitors in combined dyslipidemia patients. Derosa G., Maffioli P., D'Angelo A., Salvadeo SA., Ferrari I., Fogari E., Gravina A., Mereu R., Randazzo S., Cicero AF. 2009
Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Iso H., Kobayashi M., Ishihara J., Sasaki S., Okada K., Kita Y., Kokubo Y., Tsugane S. 2006
Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. Yamagishi K., Iso H., Date C., Fukui M., Wakai K., Kikuchi S., Inaba Y., Tanabe N., Tamakoshi A. 2008
Fish consumption, marine omega-3 fatty acids, and incidence of heart failure: a population-based prospective study of middle-aged and elderly men. Levitan EB., Wolk A., Mittleman MA. 2009
Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. de Goede J., Geleijnse JM., Boer JM., Kromhout D., Verschuren WM. 2010
Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Pietinen P., Ascherio A., Korhonen P., Hartman AM., Willett WC., Albanes D., Virtamo J. 1997
Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80. Miyagawa N., Miura K., Okuda N., Kadowaki T., Takashima N., Nagasawa SY., Nakamura Y., Matsumura Y., Hozawa A., Fujiyoshi A., Hisamatsu T., Yoshita K., Sekikawa A., Ohkubo T., Abbott RD., Okamura T., Okayama A., Ueshima H. 2014
Relationships between plasma fatty acid composition and coronary artery disease. Itakura H., Yokoyama M., Matsuzaki M., Saito Y., Origasa H., Ishikawa Y., Oikawa S., Sasaki J., Hishida H., Kita T., Kitabatake A., Nakaya N., Sakata T., Shimada K., Shirato K., Matsuzawa Y. 2011
Dietary fats and dietary cholesterol and risk of stroke in women. Larsson SC., Virtamo J., Wolk A. 2012
Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. Amiano P., Machón M., Dorronsoro M., Chirlaque MD., Barricarte A., Sánchez MJ., Navarro C., Huerta JM., Molina-Montes E., Sánchez-Cantalejo E., Urtizberea M., Arriola L., Larrañaga N., Ardanaz E., Quirós JR., Moreno-Iribas C., González CA. 2014
Association between the intake of α-linolenic acid and the risk of CHD. Vedtofte MS., Jakobsen MU., Lauritzen L., O'Reilly EJ., Virtamo J., Knekt P., Colditz G., Hallmans G., Buring J., Steffen LM., Robien K., Rimm EB., Heitmann BL. 2014
Soy and fish oil intake and mortality in a Japanese community. Nagata C., Takatsuka N., Shimizu H. 2002
Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. Morris MC., Manson JE., Rosner B., Buring JE., Willett WC., Hennekens CH. 1995
Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Nilsen DW., Albrektsen G., Landmark K., Moen S., Aarsland T., Woie L. 2001
Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China. Yuan JM., Ross RK., Gao YT., Yu MC. 2001
Dietary fatty acids and the risk of hypertension in middle-aged and older women. Wang L., Manson JE., Forman JP., Gaziano JM., Buring JE., Sesso HD. 2010
Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study. Brouwer IA., Heeringa J., Geleijnse JM., Zock PL., Witteman JC. 2006
Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study. Khaw KT., Friesen MD., Riboli E., Luben R., Wareham N. 2012
Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study. Xun P., Hou N., Daviglus M., Liu K., Morris JS., Shikany JM., Sidney S., Jacobs DR., He K. 2011
Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Yamagishi K., Nettleton JA., Folsom AR. 2008
Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. Lemaitre RN., Sitlani C., Song X., King IB., McKnight B., Spiegelman D., Sacks FM., Djoussé L., Rimm EB., Siscovick DS., Mozaffarian D. 2012
Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. de Oliveira Otto MC., Wu JH., Baylin A., Vaidya D., Rich SS., Tsai MY., Jacobs DR., Mozaffarian D. 2013
Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. Hu FB., Bronner L., Willett WC., Stampfer MJ., Rexrode KM., Albert CM., Hunter D., Manson JE. 2002
Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Finnegan YE., Minihane AM., Leigh-Firbank EC., Kew S., Meijer GW., Muggli R., Calder PC., Williams CM. 2003
Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. Ascherio A., Rimm EB., Stampfer MJ., Giovannucci EL., Willett WC. 1995
The prognostic value of adipose tissue fatty acids for incident cardiovascular disease: results from 3944 subjects in the Scottish Heart Health Extended Cohort Study. Woodward M., Tunstall-Pedoe H., Batty GD., Tavendale R., Hu FB., Czernichow S. 2011
N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study. De Goede J., Verschuren WM., Boer JM., Kromhout D., Geleijnse JM. 2013
Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study. Matsumoto C., Matthan NR., Wilk JB., Lichtenstein AH., Michael Gaziano J., Djoussé L. 2013
Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men. Virtanen JK., Mursu J., Voutilainen S., Tuomainen TP. 2009
Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study. Warensjö E., Sundström J., Vessby B., Cederholm T., Risérus U. 2008
Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. Hara M., Sakata Y., Nakatani D., Suna S., Usami M., Matsumoto S., Hamasaki T., Doi Y., Nishino M., Sato H., Kitamura T., Nanto S., Hori M., Komuro I. 2013
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. Hellstrand S., Ericson U., Gullberg B., Hedblad B., Orho-Melander M., Sonestedt E. 2014
Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Dolecek TA. 1992
Erythrocyte fatty acid composition is associated with the risk of hypertension in middle-aged and older women. Wang L., Tsai M., Manson JE., Djousse L., Gaziano JM., Buring JE., Sesso HD. 2011
Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. zz_REJECT_Moore CS., Bryant SP., Mishra GD., Krebs JD., Browning LM., Miller GJ., Jebb SA. 2006
Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. Vedtofte MS., Jakobsen MU., Lauritzen L., Heitmann BL. 2011
Fish intake and the risk of incident heart failure: the Women's Health Initiative. Belin RJ., Greenland P., Martin L., Oberman A., Tinker L., Robinson J., Larson J., Van Horn L., Lloyd-Jones D. 2011
Not Entered Yet - -
The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. Angela S Koh, An Pan, Renwei Wang, Andrew O Odegaard, Mark A Pereira, Jian-Min Yuan, Woon-Puay Koh 2013
Effects of stearidonic acid on serum triacylglycerol concentrations in overweight and obese subjects: a randomized controlled trial. Pieters DJ., Mensink RP. 2015
Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. Shaikh NA., Yantha J., Shaikh S., Rowe W., Laidlaw M., Cockerline C., Ali A., Holub B., Jackowski G. 2014
White fish reduces cardiovascular risk factors in patients with metabolic syndrome: the WISH-CARE study, a multicenter randomized clinical trial. Vázquez C., Botella-Carretero JI., Corella D., Fiol M., Lage M., Lurbe E., Richart C., Fernández-Real JM., Fuentes F., Ordóñez A., de Cos AI., Salas-Salvadó J., Burguera B., Estruch R., Ros E., Pastor O., Casanueva FF. 2014
Intake of long-chain ω-3 fatty acids from diet and supplements in relation to mortality. Bell GA., Kantor ED., Lampe JW., Kristal AR., Heckbert SR., White E. 2014
Higher erythrocyte n-3 PUFAs are associated with decreased blood pressure in middle-aged and elderly Chinese adults. Zeng FF., Sun LL., Liu YH., Xu Y., Guan K., Ling WH., Chen YM. 2014
Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose-dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women. Ras RT., Demonty I., Zebregs YE., Quadt JF., Olsson J., Trautwein EA. 2014
Dietary echium oil increases long-chain n-3 PUFAs, including docosapentaenoic acid, in blood fractions and alters biochemical markers for cardiovascular disease independently of age, sex, and metabolic syndrome. Kuhnt K., Fuhrmann C., Köhler M., Kiehntopf M., Jahreis G. 2014
Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. Ninomiya T., Nagata M., Hata J., Hirakawa Y., Ozawa M., Yoshida D., Ohara T., Kishimoto H., Mukai N., Fukuhara M., Kitazono T., Kiyohara Y. 2013
Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome. Tardivo AP., Nahas-Neto J., Orsatti CL., Dias FB., Poloni PF., Schmitt EB., Nahas EA. 2015
The effects of long-chain omega-3 fish oils and multivitamins on cognitive and cardiovascular function: a randomized, controlled clinical trial. Pase MP., Grima N., Cockerell R., Stough C., Scholey A., Sali A., Pipingas A. 2015
Not Entered Yet - -
Fish, omega-3 long-chain fatty acids, and all-cause mortality in a low-income US population: Results from the Southern Community Cohort Study. Villegas R., Takata Y., Murff H., Blot WJ. 2015
Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women. Marklund M., Leander K., Vikström M., Laguzzi F., Gigante B., Sjögren P., Cederholm T., de Faire U., Hellénius ML., Risérus U. 2015
Plasma eicosapentaenoic acid is negatively associated with all-cause mortality among men and women in a population-based prospective study. Miura K., Hughes MCB., Ungerer JP., Green AC. 2016

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