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Study Title and Description

Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults.



Key Questions Addressed
1 RCTs and other Comparative studies
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Primary Publication Information
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TitleData
Title Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults.
Author zz AlSaleh A., Maniou Z., Lewis FJ., Hall WL., Sanders TA., O'Dell SD.
Country Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, UK.
Year 2014
Numbers Pubmed ID: 24401815
14783 (internal)

Secondary Publication Information
UI Title Author Country Year
Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids. AlSaleh A., Maniou Z., Lewis FJ., Hall WL., Sanders TA., O'Dell SD. Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. 2014
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Extraction Form: Comparative Studies
Arms
Number Title Description Comments
1 "Fish oil" (DHA+EPA)
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2 Placebo
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Trial: Randomized Parallel (Omega-3 vs. Control; Omega-3 + X vs. X)
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What is the name of this study? (e.g. DART, Physician's Health Study) MARINA
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Country in which study conducted (where subjects live) UK
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: Healthy non-smoking men and women aged between 45 and 70 years. Subjects with untreated high blood pressure or raised cholesterol were excluded.
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Study Population Primary Prevention, Healthy
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Duration of Intervention 12 months
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Does the study report a subgroup analysis for an outcome of interest? No
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Baseline Characteristics
Question "Fish oil" (DHA+EPA) Placebo Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Baseline Diseases/Conditions No data entered.
Baseline characteristics, continuous No data entered.
Male, percent No data entered.
Race No data entered.
Comments about baseline data No data entered.
Baseline diet description No data entered.
Baseline omega-3 intake No data entered.
Does this study report baseline omega-3 biomarker data? No data entered.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Events (n) At Risk (N) Follow-up time Comments

Quality Dimensions
Dimension Value Notes Comments
Was the allocation sequence (RANDOMIZATION METHOD) adequately generated?
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Was ALLOCATION adequately concealed (prior to assignment)?
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Were PARTICIPANTS adequately BLINDED?
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Were OUTCOME ASSESSORS adequately BLINDED?
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Incomplete outcome data (ATTRITION BIAS) due to amount, nature or handling of incomplete outcome data
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Is there evidence of SELECTIVE OUTCOME REPORTING bias (Yes/No)?
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INTENTION-TO-TREAT analysis? (Yes/No)
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Group SIMILARITY AT BASELINE (**GENERAL**)
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Was there incomplete COMPLIANCE with interventions across groups?
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Group SIMILARITY AT BASELINE (**OMEGA-3**)
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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If outcome assessor blinding risk of bias is different for different outcomes (eg, lipids vs. MI), choose HIGH risk of bias and describe in Notes
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If attrition risk of bias is different for different outcomes (eg, lipids vs. MI) or different time points (eg, 1 year vs. 5 years), choose HIGH risk of bias and describe in Notes
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Quality Rating
No quality rating data was found.