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Study Title and Description

APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults.
Author Carvalho-Wells AL., Jackson KG., Lockyer S., Lovegrove JA., Minihane AM.
Country Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom.
Year 2012
Numbers Pubmed ID: 23134888
15030 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) SATgene
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Country in which study conducted (where subjects live) UK
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Funding source Industry only donated materials (eg, supplements)
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Conflict of interest No conflict of interest (explicitly stated)
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What type(s) of analysis is/are reported? Continuous baseline measure
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Study start date(s) nd
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Results & Comparisons


Results Data
Outcome: bp      Population: 46189
Time Point Measure All participants


0 weeks

N Analyzed 88
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 88
Mean 78
SD
SE 1
Outcome: bp      Population: 46189
Time Point Measure All participants


0 weeks

N Analyzed 44
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 44
Mean 125
SD
SE 2
Outcome: bp      Population: 46189
Time Point Measure All participants


0 weeks

N Analyzed 44
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 44
Mean 127
SD
SE 2
Outcome: bp      Population: 46190
Time Point Measure All participants


0 weeks

N Analyzed 88
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 88
Mean 78
SD
SE 1
Outcome: bp      Population: 46190
Time Point Measure All participants


0 weeks

N Analyzed 44
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 44
Mean 79
SD
SE 1
Outcome: bp      Population: 46190
Time Point Measure All participants


0 weeks

N Analyzed 44
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 44
Mean 76
SD
SE 1
Outcome: lipid      Population: 46191
Time Point Measure All participants


0 weeks

N Analyzed 88
Mean nd
SD nd
SE nd


8 weeks

N Analyzed 88
Mean 1.56
SD
SE


Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)?
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)?
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED?
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES)
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)?
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)?
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.