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Study Title and Description

Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.
Author Joensen AM., Schmidt EB., Dethlefsen C., Johnsen SP., Tjønneland A., Rasmussen LH., Overvad K.
Country Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. albert.marni.joensen@rn.dk
Year 2010
Numbers Pubmed ID: 19825219

Secondary Publication Information
UI Title Author Country Year
Marine n-3 polyunsaturated fatty acids in adipose tissue and the risk of acute coronary syndrome. Joensen AM., Overvad K., Dethlefsen C., Johnsen SP., Tjønneland A., Rasmussen LH., Schmidt EB. Department of Cardiology, Center for Cardiovascular Research, Aalborg, Denmark. albert.marni.joensen@rn.dk 2011
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n-3 Fatty acids consumed from fish and risk of atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. Frost L., Vestergaard P. Department of Cardiology and the Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark. rlg041fr@as.aaa.dk 2005
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Marine n-3 fatty acids in adipose tissue and development of atrial fibrillation: a Danish cohort study. Rix TA., Joensen AM., Riahi S., Lundbye-Christensen S., Overvad K., Schmidt EB. Department of Cardiology, Aalborg AF Study Group, Center for Cardiovascular Research, Aalborg University Hospital, , Aalborg, Denmark. 2013
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Danish Diet, Cancer, and Health cohort study (DCH)
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Country in which study conducted (where subjects live) Denmark
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: Healthy, 50-64 years old. All born in Denmark, lived in the urban areas of Copenhagen and Aarhus, and not at time of invitation registered with a cancer diagnosis in the Danish Cancer Registry. Excluded those with diagnosis of ACS or cancer before entry into study.
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Study Population Primary Prevention, Healthy
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Comment about study design: excluded 1619 individuals from study because they did not fill in questionnaie/or had diagnosis of ACS or cancer before entry into study
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... Men vs Women
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Quantiles of baseline measures
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Study start date(s) December 1993
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Male, percent 47.6
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Race nd
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Dropouts, withdrawals, etc. nd
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nd
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nd
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nd
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Baseline characteristics, continuous skip
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55.9(men), 56.2(women)
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skip
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140(men), 136(women)
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mmol/L
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5.9(men), 6.2(women)
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25.9
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skip
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3.9
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Baseline Diseases/Conditions 2.6(men), 1.5(women)
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10.0
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treatment for hypertension, Middle Quintile (according to sex-specific quintile)
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n3 Source Fish diet
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Low excluded 1619 individuals because they had diagnosis of ACS before entry into study
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes including diet and CVD risk factors
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from ONLY diet
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.