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Study Title and Description

Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake.
Author de Goede J., Geleijnse JM., Boer JM., Kromhout D., Verschuren WM.
Country Division of Human Nutrition, Wageningen University, 6700 EV, Wageningen, The Netherlands. janette.degoede@wur.nl
Year 2010
Numbers Pubmed ID: 20335635

Secondary Publication Information
UI Title Author Country Year
Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. de Goede J., Verschuren WM., Boer JM., Kromhout D., Geleijnse JM. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. 2011
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Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. de Goede J., Verschuren WM., Boer JM., Kromhout D., Geleijnse JM. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. 2012
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) MORGEN
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Country in which study conducted (where subjects live) Netherlands
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Funding source No Data on funding or affiliations
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Eligibility Criteria: 20-65 y with no history of MI or stroke
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Study Population Primary Prevention, Healthy
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... Men vs Women (in secondary study Goede 2012)
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 1993
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Male, percent 45
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Race nd
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Dropouts, withdrawals, etc. nd
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21342
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Comments about quantiles. 4 quartiles
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Baseline characteristics, continuous 41.8
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skip
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11.2
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120.4
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skip
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15.9
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76.6
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skip
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10.5
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nd
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5.2
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mmol/L
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1.0
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nd
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1.4
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mmol/L
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0.4
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nd
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25.0
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skip
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3.9
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nd
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Baseline Diseases/Conditions 0.8
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self-reported
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including diet but not CVD risk factors
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from ONLY diet
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.