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Study Title and Description

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80.
Author Miyagawa N., Miura K., Okuda N., Kadowaki T., Takashima N., Nagasawa SY., Nakamura Y., Matsumura Y., Hozawa A., Fujiyoshi A., Hisamatsu T., Yoshita K., Sekikawa A., Ohkubo T., Abbott RD., Okamura T., Okayama A., Ueshima H.
Country Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: naocom@belle.shiga-med.ac.jp.
Year 2014
Numbers Pubmed ID: 24468152

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) NIPPON-DATA
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Country in which study conducted (where subjects live) Japan
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Funding source Industry funded
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Eligibility Criteria: a total of 10,546 community residents free from CVDs at baseline(4639 men and 5907 women, aged 30 and greater) from 300 randomly selected districts from all-over Japan participated in the survey, with the participation rate of about 77%. Accordingly, these participants were thought to be representative of the Japanese population. A total of 1356 men and women excluded from this analysis for the following reasons: history of CVD (n ¼ 350), missing information (e.g., nutrition,lifestyle questionnaire) at baseline (n = 124), intake of energy more than 5000 kcal/day or less than 500 kcal/day (n¼139) and lost to follow-up due to incomplete residential addresses at the baseline survey (n = 1104).
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Study Population Primary Prevention, Healthy
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... sex, age
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What type(s) of analysis is/are reported? Quantiles of baseline measures
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Study start date(s) 1980
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Male, percent 43.8
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Race nd
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Dropouts, withdrawals, etc. 1104
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10294
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10.7
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lost to follow up due to incomplete residential addresses at the baseline survey
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Baseline characteristics, continuous 49.4 (Q2)
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13 (Q2)
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135.5 (Q2)
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21.5 (Q2)
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81.1 (Q2)
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12.1 (Q2)
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188.7 (Q2)
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mg/dL
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33.8 (Q2)
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22.7 (Q2)
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3.1 (Q2)
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Baseline Diseases/Conditions 0
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes 1356 people were excluded for the history of CVD
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including CVD risk factors, but not diet
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Yes
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) No
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from ONLY diet
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.