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Study Title and Description

Association between the intake of α-linolenic acid and the risk of CHD.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Association between the intake of α-linolenic acid and the risk of CHD.
Author Vedtofte MS., Jakobsen MU., Lauritzen L., O'Reilly EJ., Virtamo J., Knekt P., Colditz G., Hallmans G., Buring J., Steffen LM., Robien K., Rimm EB., Heitmann BL.
Country Research Unit for Dietary Studies, Institute of Preventive Medicine,Copenhagen Municipal Hospitals Region H,Copenhagen,Denmark.
Year 2014
Numbers Pubmed ID: 24964401
2742 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Pooling Project of Cohort Studies on Diet and Coronary Disease
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Country in which study conducted (where subjects live) US
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Finland
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Sweden
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: a published prospective study with at least 150 incident CHD cases; a study determining usual dietary intake using a FFQ, a dietary history interview, or a 7 d weighed food record at baseline; a validation or a repeatability study of the dietary intake assessment method
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Study Population Primary Prevention, Healthy
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... men vs. women
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Continuous baseline measure
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Study start date(s) various across cohorts: 1966, 1985, 1986, 1987, 1992
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Male, percent 35.1
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Race nd
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Baseline characteristics, continuous nd
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49 to 61
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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n3 Source Plant diet (ALA)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low risk
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low risk
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes No data available but ALA is from diet only (no ALA supplements at the time of these cohorts)
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.