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Study Title and Description

Fish consumption and cardiovascular disease in the physicians' health study: a prospective study.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Fish consumption and cardiovascular disease in the physicians' health study: a prospective study.
Author Morris MC., Manson JE., Rosner B., Buring JE., Willett WC., Hennekens CH.
Country Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Year 1995
Numbers Pubmed ID: 7598116
2746 (internal)

Secondary Publication Information
UI Title Author Country Year
Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. Wilk JB., Tsai MY., Hanson NQ., Gaziano JM., Djoussé L. Divisions of Aging and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA. 2012
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A prospective study of plasma fish oil levels and incidence of myocardial infarction in U.S. male physicians. Guallar E., Hennekens CH., Sacks FM., Willett WC., Stampfer MJ. Division of Preventive Medicine, Brigham and Women's Hospital, Boston Massachusetts. 1995
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Fish consumption and risk of sudden cardiac death. Albert CM., Hennekens CH., O'Donnell CJ., Ajani UA., Carey VJ., Willett WC., Ruskin JN., Manson JE. Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA. 1998
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Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study. Matsumoto C., Matthan NR., Wilk JB., Lichtenstein AH., Michael Gaziano J., Djoussé L. Division of Aging, Brigham and Women's Hospital, Boston, MA 02120, USA. cmatsumoto2@partners.org 2013
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Physician's Health Study
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Country in which study conducted (where subjects live) US
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: US male physicians, aged 40-84 years, with no history of MI, stroke, transient ischemic attacks, cancer (excluding nonmelanoma skin cancer), liver or renal disease, peptic ulcer, gout, current use of aspirin, other platelet-active drugs, or nonsteroidal anti-inflammatory agents.
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Comment about Eligibility Criteria: originally these participants were enrolled in MRFIT trial, which was terminated early
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Study Population Primary Prevention, Healthy
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... aspirin vs. no aspirin
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Baseline biomarker level vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 1982-1983
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Male, percent 100
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Race nd
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Dropouts, withdrawals, etc. 22071
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<14% (across all analyses)
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outcome events occurred in the first year of follow-up (<1%), failed to return the 12-month questionnaire or to answer 2 or more of the questions about seafood consumption, missing covariate data, self-reported use of fish oil supplements
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Baseline characteristics, continuous 53.2
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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24.9
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nd
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nd
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Baseline Diseases/Conditions 2.4
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5.8
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high cholesterol
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13.6
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n3 Source Fish diet
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low risk
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low risk
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes intake from supplements were explicitly excluded in the quantification of n-3 FA from FFQ because the study focused on n-3 from fish intake
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.