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Study Title and Description

Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study.
Author Brouwer IA., Heeringa J., Geleijnse JM., Zock PL., Witteman JC.
Country Wageningen Centre for Food Sciences, Wageningen, The Netherlands. ingeborg.brouwer@wur.nl
Year 2006
Numbers Pubmed ID: 16569549
6974 (internal)

Secondary Publication Information
UI Title Author Country Year
Intake of very long chain n-3 fatty acids from fish and the incidence of heart failure: the Rotterdam Study. Dijkstra SC., Brouwer IA., van Rooij FJ., Hofman A., Witteman JC., Geleijnse JM. Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands. 2009
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Rotterdam Study
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Country in which study conducted (where subjects live) Netherlands
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Funding source Industry funded
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Eligibility Criteria: people aged 55 years and older who had no atrial fibrillation (primary study) people aged 55 years and older who had no heart failure (secondary study)
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Study Population Primary Prevention, Healthy
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At baseline, did all subjects have (per eligibility criteria)...? ... Define: Other ... The population is a mixture of people
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Conflict of interest No Data regarding conflict of interest
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... age, sex, diabetes mellitus, BMI (secondary study)
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Study start date(s) 1990
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Male, percent 41% in Q3 (secondary study)
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Race nd
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Dropouts, withdrawals, etc. 2430
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7729
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31
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didn
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Baseline characteristics, continuous 67.3 (Q3 in 2nd study)
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7.6
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138
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21
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73
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11
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6.6
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mmol/L
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1.2
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1.3
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mmol/L
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0.4
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26.4
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3.6
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Diet and CVD risk factors
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Yes
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) No Data
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from BOTH diet and supplements
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.