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Study Title and Description

Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study.
Author Lemaitre RN., Sitlani C., Song X., King IB., McKnight B., Spiegelman D., Sacks FM., Djoussé L., Rimm EB., Siscovick DS., Mozaffarian D.
Country Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA. rozenl@u.washington.edu
Year 2012
Numbers Pubmed ID: 22743310
13279 (internal)

Secondary Publication Information
UI Title Author Country Year
Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. Fretts AM., Mozaffarian D., Siscovick DS., Heckbert SR., McKnight B., King IB., Rimm EB., Psaty BM., Sacks FM., Song X., Spiegelman D., Lemaitre RN. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA. amfretts@u.washington.edu 2013
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Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study. Fretts AM., Mozaffarian D., Siscovick DS., Sitlani C., Psaty BM., Rimm EB., Song X., McKnight B., Spiegelman D., King IB., Lemaitre RN. University of Washington,1730 Minor Avenue, Suite 1360,Seattle,WA98101,USA. 2014
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Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. Mozaffarian D., Lemaitre RN., King IB., Song X., Spiegelman D., Sacks FM., Rimm EB., Siscovick DS. Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02115, USA. dmozaffa@hsph.harvard.edu 2011
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Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. Mozaffarian D., Lemaitre RN., King IB., Song X., Huang H., Sacks FM., Rimm EB., Wang M., Siscovick DS. Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. dmozaffa@hsph.harvard.edu 2013
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Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. Wu JH., Lemaitre RN., King IB., Song X., Sacks FM., Rimm EB., Heckbert SR., Siscovick DS., Mozaffarian D. Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. 2012
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Cardiovascular Health Study
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Country in which study conducted (where subjects live) US
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Funding source Authors report industry affiliation
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Eligibility Criteria: The cohort consisted of 5201 noninstitutionalized men and women aged $65 y, recruited in 1989–1990, plus an additional 687 black participants recruited in 1992–1993.
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Comment about Eligibility Criteria: Each paper excluded participants with their outcome of interest at baseline.
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Study Population Primary Prevention, Healthy
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Conflict of interest ... Specify Conflict of interest stated ... one author reports that he is receiving grants from pharmaceutical companies
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... age, sex, diabetes, BMI, genotype at rs1535, phospholipid linoleic acid, or low or no fish consumption
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Baseline biomarker level vs. outcomes
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Study start date(s) 1989
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Male, percent 36.1
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Race 87.8
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11.7
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Baseline characteristics, continuous 73
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IQR 71-98
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74
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5
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Baseline Diseases/Conditions 24
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n3 Source Plant diet (ALA)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including diet and CVD risk factors
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes biomarker study
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.