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Study Title and Description

Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.
Author de Oliveira Otto MC., Wu JH., Baylin A., Vaidya D., Rich SS., Tsai MY., Jacobs DR., Mozaffarian D.
Country Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Year 2013
Numbers Pubmed ID: 24351702
13286 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Multi-Ethnic Study of Atherosclerosis (MESA)
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Country in which study conducted (where subjects live) US
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: study in US, aged 45-84 years, free of clinical CVD at baseline
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Comment about Eligibility Criteria: N=6814 participants in MESA, reduced to subset of N=2837, who had plasma phospholipid FA measurements, data met quality control checks, and were not taking fish oils (under study design)
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Study Population Primary Prevention, Healthy
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Comment about study design: N=2837 US adults, multiethnic cohort
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... for ethnicity
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Baseline biomarker level vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 2000
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Male, percent 46.8
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Race 26
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n=724/2837
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25
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n=697/2837
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nd
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nd
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25
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n=705/2837
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nd
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nd
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Chinese, n=711/2837
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Dropouts, withdrawals, etc. nd
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Baseline characteristics, continuous 61.5
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skip
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10.2
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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27.9
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skip
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5.5
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nd
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Baseline Diseases/Conditions 13.1
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including diet and CVD risk factors (eg, lipids, BP, DM)
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from ONLY diet
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.