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Study Title and Description

Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men.
Author Ascherio A., Rimm EB., Stampfer MJ., Giovannucci EL., Willett WC.
Country Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
Year 1995
Numbers Pubmed ID: 7885425
142 (internal)

Secondary Publication Information
UI Title Author Country Year
Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Mozaffarian D., Ascherio A., Hu FB., Stampfer MJ., Willett WC., Siscovick DS., Rimm EB. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA. dmozaffa@hsph.harvard.edu 2005
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Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Health Professional Follow-up Study
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Country in which study conducted (where subjects live) US
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Funding source No Data on funding or affiliations
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Eligibility Criteria: Inclusion Criteria: mail health professionals; aged 40 to 75. Exclusion Criteria: previously diagnosed stroke, myocardial infarction, coronary artery surgery, angina pectoris, peripheral arterial disease, diabetes mellitus, transient ischemic attack, or other cardiovascular disease, stroke, cancer; Daily caloric intake outside range of 800 and 4200 kcal; incompleteness of data on food consumption (more than 70 blanks out of 131 listed food items); no information on fish intake at baseline
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Study Population Primary Prevention, Healthy
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Conflict of interest No Data regarding conflict of interest
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... men with diabetes, hypertension, or hyperlipidemia; knowledge of serum cholesterol level at baseline; Use of fish oil supplement use
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Study start date(s) 1986
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Male, percent 100%
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Race nd
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Dropouts, withdrawals, etc. 6.0%
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51529
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Baseline characteristics, continuous 53
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9.6
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0.1
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40,75
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203
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mg/dL
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25.5
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0.02
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Baseline Diseases/Conditions 19.3
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2.4
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n3 Source Fish diet
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including diet and CVD risk factors
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from BOTH diet and supplements
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. Yes Some issues with genralizability: study focus on men without history of diabetes and cardiovascular diseases.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.