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Study Title and Description

Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men.
Author Virtanen JK., Mursu J., Voutilainen S., Tuomainen TP.
Country Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland. jyrki.virtanen@uku.fi
Year 2009
Numbers Pubmed ID: 19933935

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Kuopio Ischemic Heart Disease Risk Factor Study
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Country in which study conducted (where subjects live) Finland
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: men who were 42, 48, 54, or 60 years old at the baseline examination. Subjects with a history of AF at baseline were excluded from the analyses. Also excluded men with missing data on serum PUFAs or hair methylmercury concentration.
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Comment about Eligibility Criteria: The men who wereincluded were younger and healthier, including having a lower prevalence of CVD, diabetes mellitus, hypertension, and current smoking, and they had a higher education and income than those who were excluded
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Study Population Primary Prevention, Healthy
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? No
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What type(s) of analysis is/are reported? Quantiles of baseline measures
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Study start date(s) 1984
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Male, percent 100
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Race nd
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Dropouts, withdrawals, etc. 3
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1941
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0.15%
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Baseline characteristics, continuous 52.8
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5.3
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nd
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nd
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nd
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nd
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nd
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Baseline Diseases/Conditions 4.9
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nd
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nd
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2174
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46.5
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nd
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nd
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nd
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5.6
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1.9
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nd
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nd
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nd
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nd
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nd
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including CVD risk factors but not diet
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)?
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.