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Study Title and Description

Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial.
Author Dolecek TA.
Country Department of Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Year 1992
Numbers Pubmed ID: 1579579

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Multiple Risk Factor Intervention Trial
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Country in which study conducted (where subjects live) US
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Funding source Industry funded
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Comment about Eligibility Criteria: 12866 middle-aged men determined to be at high risk of CHD based on smoking status, dbp, and serum cholesterol levels
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Study Population Primary Prevention, Increased CVD Risk (ie, diabetes, metabolic syndrome*, hypertension, dyslipidemia, or chronic kidney disease)
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At baseline, did all subjects have (per eligibility criteria)...? ... Define: Other ... a mix of population
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Conflict of interest No Data regarding conflict of interest
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? No
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What type(s) of analysis is/are reported? Baseline intake (eg, from FFQ) vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 1973
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Male, percent 100%
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Race nd
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Dropouts, withdrawals, etc. nd
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Baseline characteristics, continuous nd
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skip
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35,57
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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nd
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n3 Source Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? No Data
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including CVD risk factors, but not diet
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Yes
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) No Data
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Instrument reported but no adequate description regarding n-3 FA intake measurement
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? No
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Additional Bias: Bias due to problems not covered elsewhere in the table.
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes.
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Quality Rating
No quality rating data was found.