This is the old version of SRDR. The next, SRDRplus is available! Registration of your SRDRPlus account is free and approval is automatic. Click Here to register an SRDRPlus account.

Advanced Search

Study Preview



Study Title and Description

Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women.



Key Questions Addressed
1 RCTs and other Comparative studies
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women.
Author zz_REJECT_Moore CS., Bryant SP., Mishra GD., Krebs JD., Browning LM., Miller GJ., Jebb SA.
Country Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK. carmel.moore@mrc-hnr.cam.ac.uk
Year 2006
Numbers Pubmed ID: 17027436

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Comparative Studies
Arms
Number Title Description Comments
1 Fish white fish + rapeseed oil
  • Comments Comments (
    0
    ) |
2 Fish white fish + sunflower oil
  • Comments Comments (
    0
    ) |
3 Fish oily fish + rapeseed oil
  • Comments Comments (
    0
    ) |
4 Fish oily fish + sunflower oil
  • Comments Comments (
    0
    ) |
5 No intervention
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Trial: Randomized Factorial Design
  • Comments Comments (
    0
    ) |
Country in which study conducted (where subjects live) UK
  • Comments Comments (
    0
    ) |
Funding source Industry only donated materials (eg, supplements)
  • Comments Comments (
    0
    ) |
Eligibility Criteria: entry criteria, which included a body mass index (BMI) between 25 and 40 kg/m2; age between 35 and 65 y; not taking regular oil supplements; not currently prescribed non-steroidal anti-inflammatory drugs, aspirin, steroids, immunosuppressants, or lipid-lowering drugs; no known diagnosis of diabetes, hypertension, hyperlipidemia, asthma, or chronic inflammatory diseases; and, in female subjects, no known or planned pregnancies
  • Comments Comments (
    0
    ) |
Study Population Primary Prevention, Healthy
  • Comments Comments (
    0
    ) |
Duration of Intervention 24 weeks
  • Comments Comments (
    0
    ) |
At baseline, did all subjects have (per eligibility criteria)...? ... Define: Obesity/Overweight ... body mass index (BMI) between 25 and 40 kg/m2
  • Comments Comments (
    0
    ) |
Conflict of interest No Data regarding conflict of interest
  • Comments Comments (
    0
    ) |
Does the study report a subgroup analysis for an outcome of interest? No
  • Comments Comments (
    0
    ) |
Does the study report a regression analysis with interaction terms for an outcome of interest? No
  • Comments Comments (
    0
    ) |
Does the study report an analysis of the association between n-3 biomarkers and an outcome of interest? No
  • Comments Comments (
    0
    ) |
Study start date(s) nd
  • Comments Comments (
    0
    ) |


Baseline Characteristics
Question Fish Fish Fish Fish No intervention Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up AnswerFollow-up AnswerFollow-up AnswerFollow-up
Baseline Diseases/Conditions No data entered.
Baseline characteristics, continuous 51 51 50 50 51
  • Comments Comments (
    0
    ) |
9 9 9 8 9
  • Comments Comments (
    0
    ) |
126.0 123.2 129.5 129.9 123.1
  • Comments Comments (
    0
    ) |
17.1 13.7 15.6 15.9 23.4
  • Comments Comments (
    0
    ) |
73.3 73.0 77.3 74.2 72.6
  • Comments Comments (
    0
    ) |
10.6 10.2 9.6 9.2 12.1
  • Comments Comments (
    0
    ) |
5.13 5.70 5.67 5.38 5.27
  • Comments Comments (
    0
    ) |
mmol/L mmol/L mmol/L mmol/L mmol/L
  • Comments Comments (
    0
    ) |
0.9 1.12 0.76 0.85 0.90
  • Comments Comments (
    0
    ) |
3.26 3.58 3.78 3.38 3.34
  • Comments Comments (
    0
    ) |
mmol/L mmol/L mmol/L mmol/L mmol/L
  • Comments Comments (
    0
    ) |
0.84 0.90 0.79 0.77 0.83
  • Comments Comments (
    0
    ) |
1.35 1.43 1.34 1.42 1.37
  • Comments Comments (
    0
    ) |
mmol/L mmol/L mmol/L mmol/L mmol/L
  • Comments Comments (
    0
    ) |
0.36 0.38 0.26 0.36 0.42
  • Comments Comments (
    0
    ) |
1.17 1.44 1.21 1.24 1.21
  • Comments Comments (
    0
    ) |
mmol/L mmol/L mmol/L mmol/L mmol/L
  • Comments Comments (
    0
    ) |
0.48 0.83 0.51 0.66 0.71
  • Comments Comments (
    0
    ) |
30.5 30.0 30.9 31.9 31.2
  • Comments Comments (
    0
    ) |
3.5 4.1 3.7 4.2 4.5
  • Comments Comments (
    0
    ) |
Male, percent 34.75
  • Comments Comments (
    0
    ) |
Race nd
  • Comments Comments (
    0
    ) |
Comments about baseline data No data entered.
Baseline diet description No data entered.
Baseline omega-3 intake No data entered.
Does this study report baseline omega-3 biomarker data? No No No No No Yes
  • Comments Comments (
    0
    ) |



Results & Comparisons


Results Data
Outcome: lipid      Population: 56172
Time Point Measure Fish Fish Fish Fish No intervention


0 weeks

N Analyzed 22 27 29 27 28
Mean 1.17 1.44 1.21 1.24 1.21
SD 0.48 0.83 0.51 0.66 0.71


12 weeks

N Analyzed 22 27 29 27 28
Mean 1.11 1.33 1.07 1.25 1.27
SD 0.48 0.52 0.33 0.82 0.74


24 weeks

N Analyzed 22 27 29 27 28
Mean 1.25 1.44 1.09 1.20 1.15
SD 0.62 0.53 0.30 0.68 0.54
Outcome: lipid      Population: 56173
Time Point Measure Fish Fish Fish Fish No intervention


0 weeks

N Analyzed 22 27 29 27 28
Mean 3.26 3.58 3.78 3.38 3.34
SD 0.84 0.90 0.79 0.77 0.83


12 weeks

N Analyzed 22 27 29 27 28
Mean 3.17 3.39 3.76 3.45 3.35
SD 0.81 1.06 0.95 0.83 1.05


24 weeks

N Analyzed 22 27 29 27 28
Mean 3.14 3.67 3.97 3.50 3.40
SD 0.67 0.87 0.80 0.76 0.92
Outcome: lipid      Population: 56174
Time Point Measure Fish Fish Fish Fish No intervention


0 weeks

N Analyzed 22 27 29 27 28
Mean 1.35 1.43 1.34 1.42 1.37
SD 0.36 0.38 0.26 0.36 0.42


12 weeks

N Analyzed 22 27 29 27 28
Mean 1.28 1.28 1.32 1.42 1.28
SD 0.31 0.30 0.30 0.44 0.42


24 weeks

N Analyzed 22 27 29 27 28
Mean 1.34 1.42 1.42 1.45 1.40
SD 0.31 0.33 0.29 0.41 0.44
Outcome: bp      Population: 56175
Time Point Measure Fish Fish Fish Fish No intervention


0 weeks

N Analyzed 22 27 29 27 28
Mean 126.0 123.2 129.5 129.9 123.1
SD 17.1 13.7 15.6 15.9 23.4


12 weeks

N Analyzed 22 27 29 27 28
Mean 122.0 122.8 124.6 122.7 119.6
SD 16.2 15.6 17.5 15.0 19.8


24 weeks

N Analyzed 22 27 29 27 28
Mean 123.0 118.4 120.9 120.7 120.9
SD 16.9 19.1 14.7 14.7 20.3
Outcome: bp      Population: 56176
Time Point Measure Fish Fish Fish Fish No intervention


0 weeks

N Analyzed 22 27 29 27 28
Mean 73.3 73.0 77.3 74.2 72.6
SD 10.6 10.2 9.6 9.2 12.1


12 weeks

N Analyzed 22 27 29 27 28
Mean 67.6 70.0 74.0 71.4 68.3
SD 9.1 10.0 10.2 8.6 12.6


24 weeks

N Analyzed 22 27 29 27 28
Mean 70.4 67.9 70.7 68.9 69.1
SD 11.0 11.3 8.0 8.8 10.1

Adverse Events
Arm or Total Title Description Events (n) At Risk (N) Follow-up time Comments

Quality Dimensions
Dimension Value Notes Comments
Was the allocation sequence (RANDOMIZATION METHOD) adequately generated? Unclear
  • Comments Comments (
    0
    ) |
Was ALLOCATION adequately concealed (prior to assignment)? High no allocation concealment
  • Comments Comments (
    0
    ) |
Were PARTICIPANTS adequately BLINDED? High no blinding
  • Comments Comments (
    0
    ) |
Were OUTCOME ASSESSORS adequately BLINDED? High no blinding
  • Comments Comments (
    0
    ) |
Incomplete outcome data (ATTRITION BIAS) due to amount, nature or handling of incomplete outcome data Low
  • Comments Comments (
    0
    ) |
Is there evidence of SELECTIVE OUTCOME REPORTING bias (Yes/No)? No
  • Comments Comments (
    0
    ) |
INTENTION-TO-TREAT analysis? (Yes/No) Yes
  • Comments Comments (
    0
    ) |
Group SIMILARITY AT BASELINE (**GENERAL**)
  • Comments Comments (
    0
    ) |
Was there incomplete COMPLIANCE with interventions across groups? Low
  • Comments Comments (
    0
    ) |
Group SIMILARITY AT BASELINE (**OMEGA-3**) Unclear
  • Comments Comments (
    0
    ) |
Additional Bias: Bias due to problems not covered elsewhere in the table.
  • Comments Comments (
    0
    ) |
If outcome assessor blinding risk of bias is different for different outcomes (eg, lipids vs. MI), choose HIGH risk of bias and describe in Notes
  • Comments Comments (
    0
    ) |
If attrition risk of bias is different for different outcomes (eg, lipids vs. MI) or different time points (eg, 1 year vs. 5 years), choose HIGH risk of bias and describe in Notes
  • Comments Comments (
    0
    ) |

Quality Rating
No quality rating data was found.