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Study Title and Description

Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.
Author Ninomiya T., Nagata M., Hata J., Hirakawa Y., Ozawa M., Yoshida D., Ohara T., Kishimoto H., Mukai N., Fukuhara M., Kitazono T., Kiyohara Y.
Country Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: nino@intmed2.med.kyushu-u.ac.jp.
Year 2013
Numbers Pubmed ID: 24267237

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study) Hisayama Study
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Country in which study conducted (where subjects live) Japan
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Funding source Industry funded
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Authors report industry affiliation
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Eligibility Criteria: Briefly, a total of 3328 residents aged 40 years or older (77.6% of the total population in this age group) underwent the examination. After excluding 30 subjects who did not consent to participate in the study, 190 subjects with a history of cardiovascular disease, and 5 subjects without available data on serum fatty acid levels, the remaining 3103 participants were enrolled in the study.
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Study Population Primary Prevention, Healthy
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Conflict of interest ... Specify Conflict of interest stated ... Additionally, this study was sponsored by Mochida pharmaceutical Co., Ltd. (Tokyo, Japan). The sponsor of the study had no role in the study design, conduct of the study, data collection, data interpretation or preparation of the report. Toshiharu Ninomiya and Yutaka Kiyohara received honoraria for lecture fees from Mochida Pharmaceutical Co., Ltd. Other authors declare that they have no competing interests.
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... n-3/n-6 ratio
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What type(s) of analysis is/are reported? Baseline biomarker level vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 2002
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Male, percent 42.0
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Baseline characteristics, continuous 61.3
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12.5
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131.8
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21.1
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78.4
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11.9
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5.28
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mmol/L
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0.92
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1.62
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mmol/L
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0.42
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mmol/L
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1.10
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IQR 0.78, 1.63
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23.1
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3.4
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Baseline Diseases/Conditions 16.9
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42.6
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n3 Source No Data / Unclear
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Low
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) Low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Yes Measured n-3 FA from ONLY diet
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.