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Study Title and Description

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women.



Key Questions Addressed
2 Observational studies (longitudinal; quantile or continuous analysis)
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Primary Publication Information
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TitleData
Title Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women.
Author Marklund M., Leander K., Vikström M., Laguzzi F., Gigante B., Sjögren P., Cederholm T., de Faire U., Hellénius ML., Risérus U.
Country From Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden (M.M., P.S., T.C., U.R.); Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine (K.L., M.V., F.L., B.G., U.d.F.) and Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyds Hospital (B.G.), Karolinska Institutet, Stockholm, Sweden; and Department of Medicine, Cardiology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (M.-L.H.).
Year 2015
Numbers Pubmed ID: 26085453
593 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Observational Studies
Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Observational: Prospective, longitudinal study of intake (eg, FFQ, biomarker)
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What is the name of this study? (e.g. DART, Physician's Health Study)
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Country in which study conducted (where subjects live) Sweden
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Funding source No industry relationship reported (funding or affiliations reported)
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Eligibility Criteria: all men and women living in Stockholm County who turned 60 years of age between July 1, 1997, and June 30, 1998.
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Comment about Eligibility Criteria:
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Study Population Primary Prevention, Healthy
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Primary Prevention, Increased CVD Risk (ie, diabetes, metabolic syndrome*, hypertension, dyslipidemia, or chronic kidney disease)
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Comment about study design:
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Conflict of interest No conflict of interest (explicitly stated)
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Does the study report a subgroup or predictor (regression) analysis for an outcome of interest? ... Which subgroups/predictors? Yes ... sex
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What type(s) of analysis is/are reported? Baseline biomarker level vs. outcomes
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Quantiles of baseline measures
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Study start date(s) 1997-1999
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Male, percent 47.2
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Race
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nd
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Dropouts, withdrawals, etc. nd
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Comments about quantiles. quartiles
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Baseline characteristics, continuous
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138
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22
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84
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11
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5.99
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mmol/L
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1.06
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3.89
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mmol/L
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0.93
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1.50
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mmol/L
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0.39
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mmol/L
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1.1
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quartiles 1,3 (0.8, 1.6)
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26.7
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4.1
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Baseline Diseases/Conditions 6.3
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3.5
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drug-treated hypercholesterolemia
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16
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drug-treated
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n3 Source Marine oil supplement
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Diet (Total)
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Selection bias (NOT NESTED CASE CONTROL): Is there clear demonstration that the outcome of interest was not present at the start of the study (baseline)? Yes
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Comparability/Adjustment (ALL OBSERVATIONAL STUDIES): Were the analyses adjusted for confounders (or other factors)? Yes Including CVD risk factors, but not diet
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Outcome assessment (ALL STUDIES): Were OUTCOME ASSESSORS adequately BLINDED? Unsure
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Incomplete outcome data (attrition bias) due to amount, nature or handling of incomplete outcome data (ALL STUDIES) low
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Nutrition, FFQ Baseline intake: Was the dietary assessment instrument (eg, FFQ) described to have measured n-3 FA (ALL STUDIES WITH FFQ)? Not Applicable
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Nutrition, Baseline data: Were the ranges or distributions of the nutrient exposures adequately reported (ie, quantile means/medians SD and/or ranges) (ALL OBSERVATIONAL STUDIES)? No No SD or ranges
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Additional Bias: Bias due to problems not covered elsewhere in the table. No
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Do any specific outcomes have a high risk of bias (different than others)? If so, describe in Notes. No
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Quality Rating
No quality rating data was found.