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Project: Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies

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Project Summary

Title and Description

Title Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies
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Description The objective of this project is to systematically review and quantitatively evaluate randomized controlled trials and prospective cohort studies, separately, that examined the relationship between low-calorie sweeteners and body weight and composition.
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Methodology A systematic literature search identified 15 randomized controlled trials and 9 prospective cohort studies that examined low-calorie sweeteners from foods or beverages, or low-calorie sweeteners consumed as tabletop sweeteners. Meta-analyses generated weighted mean differences in body weight and composition values between the low-calorie sweetener and control groups among randomized controlled trials, and weighted mean correlations for low-calorie sweetener intake and these parameters among prospective cohort studies.
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DOI https://dx.doi.org/10.7301/Z0V985ZK
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Funding Source Supported by funding from the North American Branch of the International Life Sciences Institute.
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Notes
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Key Questions

1 What is the relationship between low-calorie sweeteners and body weight and composition in randomized controlled studies?
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2 What is the relationship between low-calorie sweeteners and body weight and composition in prospective observational cohort studies?
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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Extraction form for randomized controlled trials Ellen Chang 1
Extraction form for prospective observational studies Ellen Chang 2


Associated Studies (each link opens a new tab)

Title Author Year
The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. Blackburn GL., Kanders BS., Lavin PT., Keller SD., Whatley J. 1997
A trial of sugar-free or sugar-sweetened beverages and body weight in children. de Ruyter JC., Olthof MR., Seidell JC., Katan MB. 2012
A randomized trial of sugar-sweetened beverages and adolescent body weight. Ebbeling CB., Feldman HA., Chomitz VR., Antonelli TA., Gortmaker SL., Osganian SK., Ludwig DS. 2012
Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Ebbeling CB., Feldman HA., Osganian SK., Chomitz VR., Ellenbogen SJ., Ludwig DS. 2006
Extended use of foods modified in fat and sugar content: nutritional implications in a free-living female population. Gatenby SJ., Aaron JI., Jack VA., Mela DJ. 1997
Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers. Gostner A., Schäffer V., Theis S., Menzel T., Lührs H., Melcher R., Schauber J., Kudlich T., Dusel G., Dorbath D., Kozianowski G., Scheppach W. 2005
An evaluation of the effect of aspartame on weight loss. Kanders BS., Lavin PT., Kowalchuk MB., Greenberg I., Blackburn GL. 1988
Effects of aspartame in young persons during weight reduction. Knopp RH., Brandt K., Arky RA. 1976
Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Maersk M., Belza A., Stødkilde-Jørgensen H., Ringgaard S., Chabanova E., Thomsen H., Pedersen SB., Astrup A., Richelsen B. 2012
Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults. Njike VY., Faridi Z., Shuval K., Dutta S., Kay CD., West SG., Kris-Etherton PM., Katz DL. 2011
Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Raben A., Vasilaras TH., Møller AC., Astrup A. 2002
Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period. Reid M., Hammersley R., Hill AJ., Skidmore P. 2007
Effects of sucrose drinks on macronutrient intake, body weight, and mood state in overweight women over 4 weeks. Reid M., Hammersley R., Duffy M. 2010
Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Tate DF., Turner-McGrievy G., Lyons E., Stevens J., Erickson K., Polzien K., Diamond M., Wang X., Popkin B. 2012
Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. Tordoff MG., Alleva AM. 1990
Sugar-added beverages and adolescent weight change. Berkey CS., Rockett HR., Field AE., Gillman MW., Colditz GA. 2004
Patterns of weight change and their relation to diet in a cohort of healthy women. Colditz GA., Willett WC., Stampfer MJ., London SJ., Segal MR., Speizer FE. 1990
Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Fowler SP., Williams K., Resendez RG., Hunt KJ., Hazuda HP., Stern MP. 2008
Is sugar-sweetened beverage consumption associated with increased fatness in children? Johnson L., Mander AP., Jones LR., Emmett PM., Jebb SA. -- Not Found --
Longitudinal associations between key dietary behaviors and weight gain over time: transitions through the adolescent years. Laska MN., Murray DM., Lytle LA., Harnack LJ. 2012
Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA). Nettleton JA., Lutsey PL., Wang Y., Lima JA., Michos ED., Jacobs DR. 2009
Beverage consumption is not associated with changes in weight and body mass index among low-income preschool children in North Dakota. Newby PK., Peterson KE., Berkey CS., Leppert J., Willett WC., Colditz GA. 2004
Dietary factors in relation to weight change among men and women from two southeastern New England communities. Parker DR., Gonzalez S., Derby CA., Gans KM., Lasater TM., Carleton RA. 1997
Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. Schulze MB., Manson JE., Ludwig DS., Colditz GA., Stampfer MJ., Willett WC., Hu FB. 2004




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