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Study Title and Description

An evaluation of the effect of aspartame on weight loss.



Key Questions Addressed
1 What is the relationship between low-calorie sweeteners and body weight and composition in randomized controlled studies?
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Primary Publication Information
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TitleData
Title An evaluation of the effect of aspartame on weight loss.
Author Kanders BS., Lavin PT., Kowalchuk MB., Greenberg I., Blackburn GL.
Country Cancer Research Institute, New England Deaconess Hospital, Boston, MA 02215.
Year 1988
Numbers Pubmed ID: 3190220
13296 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Extraction form for randomized controlled trials
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
Author, year Kanders, 1988
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Country US
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Baseline age range (y) or mean (SD) 26-60
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Children, Adolescents, or Adults Adults
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Other population characteristics Free-living overweight/obese adults, 10% with diabetes, 61% hypertensive
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Baseline BMI (mean) M: 36.5 F: 38
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Intervention details Participants assigned to medically-supervised, hypocaloric, controlled diet (1200 kcal) [or BDD supplemented with aspartame]
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Tx arm Balanced deficit diet (BDD) supplemented with aspartame (milk exchanges were pudding or milk shakes sweetened with aspartame; also encouraged to use low-kcal sweetener, aspartame, diet sodas, and gelatin as desired)
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Beverage (B), Food (F), or Supplement (S) BFS
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Weight loss diet in tx? Y
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Control arm BDD; instructed to avoid use of all aspartame- or saccharin-sweetened products
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Weight loss diet in control? Y
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Energy intake significantly less in tx? N
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Duration (wk) 12
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No. analyzed (tx) M: 4 F: 24
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No. analyzed (control) M: 7 F: 21
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Intake of sweetener (tx) mean (SD) 383 mg/d aspartame
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Sex (M, F) 11 M 45 F
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Outcome measure 1 BMI
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Outcome measure 2 Body weight (kg)
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Outcome measure 3 Fat mass (kg)
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Outcome measure 4
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Pre-study mean outcome 1 (tx) M: 37.00 F: 38.00
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Pre-study mean outcome 2 (tx) M: 111.40 F: 104.50
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Pre-study mean outcome 3 (tx) M: 34.50 F: 41.80
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Pre-study mean outcome 4 (tx)
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Pre-study SD outcome 1 (tx) NR
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Pre-study SD outcome 2 (tx) NR
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Pre-study SD outcome 3 (tx) NR
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Pre-study SD outcome 4 (tx)
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Post-study mean outcome 1 (tx) M: 33.60 F: 35.20
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Post-study mean outcome 2 (tx) M: 100.90 F: 101.10
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Post-study mean outcome 3 (tx) M: 24.40 F: 37.50
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Post-study mean outcome 4 (tx)
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Post-study SD outcome 1 (tx) NR
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Post-study SD outcome 2 (tx) NR
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Post-study SD outcome 3 (tx) NR
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Post-study SD outcome 4 (tx)
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Pre-study mean outcome 1 (control) M: 36.00 F: 38.00
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Pre-study mean outcome 2 (control) M: 104.50 F:102.70
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Pre-study mean outcome 3 (control) M: 33.50 F: 42.10
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Pre-study mean outcome 4 (control)
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Pre-study SD outcome 1 (control) NR
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Pre-study SD outcome 2 (control) NR
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Pre-study SD outcome 3 (control) NR
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Pre-study SD outcome 4 (control)
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Post-study mean outcome 1 (control) M: 31.90 F: 35.90
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Post-study mean outcome 2 (control) M: 92.30 F: 100.10
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Post-study mean outcome 3 (control) M: 22.10 F: 39.30
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Post-study mean outcome 4 (control)
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Post-study SD outcome 1 (control) NA
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Post-study SD outcome 2 (control) NA
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Post-study SD outcome 3 (control) NA
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Post-study SD outcome 4 (control) NA
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Mean change outcome 1 (tx) NA
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Mean change outcome 2 (tx) NA
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Mean change outcome 3 (tx) NA
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Change SD outcome 1 (tx) NA
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Change SD outcome 2 (tx) NA
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Change SD outcome 3 (tx) NA
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Mean change outcome 1 (control) NA
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Mean change outcome 2 (control) NA
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Mean change outcome 3 (control) NA
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Change SD outcome 1 (control) NA
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Change SD outcome 2 (control) NA
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Change SD outcome 3 (control) NA
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Notes converted body fat% (reported in study) to fat mass (kg); run sensitivity analysis without this study
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Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
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Quality Rating
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