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Study Title and Description

Patterns of weight change and their relation to diet in a cohort of healthy women.



Key Questions Addressed
2 What is the relationship between low-calorie sweeteners and body weight and composition in prospective observational cohort studies?
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Primary Publication Information
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TitleData
Title Patterns of weight change and their relation to diet in a cohort of healthy women.
Author Colditz GA., Willett WC., Stampfer MJ., London SJ., Segal MR., Speizer FE.
Country Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA.
Year 1990
Numbers Pubmed ID: 2349925
13306 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Extraction form for prospective observational studies
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Author, year Colditz, 1990
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Cohort name NHS
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Country US
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Baseline age, y 30-55
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Follow-up, y (between diet and outcome) 4
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Children/ adolescents (C) or adults (A) A
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Other population characteristics Registered nurses
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Mean BMI 23.4
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Author-defined exposure Baseline saccharin intake
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Assigned exposure Saccharin intake
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Beverage (B), Food (F), or Supplement (S) S
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Exposure assessment method FFQ
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Diet assessment method Validated FFQ
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Year diet assessed 1980
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Analytic cohort no. 31940
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Sex (M, F) 31940 F
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Author-defined outcome 1 Weight change (kg)
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Author-defined outcome 2
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Assigned outcome 1 BW change
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Assigned outcome 2
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Exposure unit mg/d
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β1 for Δ in outcome per unit increase in baseline exposure 0.0024
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β2 for Δ in outcome per unit increase in baseline exposure
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SE1 for β (baseline exposure) NR
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SE2 for β (baseline exposure)
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t-statistic (baseline exposure and outcome) 7.4
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β for Δ in outcome per unit change in exposure overtime NA
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SE for β (change in exposure overtime) NA
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t-statistic (baseline exposure and outcome overtime) NA
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Quantiles Tertiles
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Q1 intake 0
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Highest Q intake >5.8
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Q1 change in outcome 0.39
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Q1 SD change in outcome 0.35
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Highest Q mean change in outcome 1.1
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Highest Q SD change in outcome 0.47
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RR (highest vs. lowest) NA
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LL (highest vs. lowest) NA
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UL (highest vs. lowest) NA
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Dose-response RR NA
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Dose-response LL NA
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Dose-response UL NA
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Statistical adjustments age, baseline BMI, and total energy intake for continuous; none for tertiles
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MV-adjusted (Y/N) Y
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Energy-adjusted (Y/N) Y
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Baseline BMI/ weight-adjusted Y
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Notes Cohort followed for 8y but 4y change (1980-1984) in weight was examined
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Baseline Characteristics
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Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

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