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Study Title and Description

Sucralose affects glycemic and hormonal responses to an oral glucose load.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Sucralose affects glycemic and hormonal responses to an oral glucose load.
Author Pepino MY, Tiemann CD, Patterson BW, Wice BM, Klein S.
Country Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA. ypepino@dom.wustl.edu
Year 2013
Numbers Pubmed ID: 23633524

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Sucralose
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Comparator water
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LCS vs sugar/ or others 2
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Outcomes metabolic response to glucose ingestion; insulin sensitivity and clearance; and B-cell function (all via modified 5hr oral glucose tolerance test); -cpeptide; glucagon
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 35.1
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Age 35.1
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% Male 0.118
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BMI 42.3
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Intervention Form Beverage
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Sample size 17
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Number analyzed (intervention) 17
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Number analyzed (control) 17
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Baseline health Obese
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Baseline health (coded) overweight
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Duration 5 hr (2x)
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study test the hypothesis that sucralose ingestion alters the glycemic and hormonal responses to glucose ingestion in obese subjects who are not regular users of NNS
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Funding source NIH Clinical and Translational Sciences Award
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Funding(coded) Government
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Internal
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