Advanced Search

Study Preview



Study Title and Description

Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women.
Author Kilpatrick LA, Coveleskie K, Connolly L, Labus JS, Ebrat B, Stains J, Jiang Z, Suyenobu BY, Raybould HE, Tillisch K, Mayer EA.
Country Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, Los Angeles, California; Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, California. Electronic address: lakilpatrick@mednet.ucla.edu.
Year 2014
Numbers Pubmed ID: 24480616

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
  • Comments Comments (
    0
    ) |
Intervention/Exposure Stevia
  • Comments Comments (
    0
    ) |
Comparator Sucrose
  • Comments Comments (
    0
    ) |
LCS vs sugar/ or others 1
  • Comments Comments (
    0
    ) |
Outcomes anxiety and depression ratings (Hospital Anxiety and Depression Scale); symptom; taste; satisfaction and appetite ratings; desire for sweetness ratings; with fMRI; measured oscillatory brain dynamics in multiple frequency bands:; changes in frequency distribution in the brainstem encompassing the NTS; the periaqueductal gray; locus coeruleus; and other pontine and medullary regions; additional analyses of NTS and hypothalamus (e.g. mean and frequency power); differences in NTS and hypothalamus frequency power during 1st and 2nd half of imaging sessions; Relationship between NTS and hypothalamus frequency power and subjective ratings.; Functional connectivity of the NTS and hypothalamus
  • Comments Comments (
    0
    ) |
Study Design RCT-c
  • Comments Comments (
    0
    ) |
Country/Region US
  • Comments Comments (
    0
    ) |
Age (mean or range) 26.3
  • Comments Comments (
    0
    ) |
Age 26.3
  • Comments Comments (
    0
    ) |
% Male 0
  • Comments Comments (
    0
    ) |
BMI 27.61
  • Comments Comments (
    0
    ) |
Intervention Form Beverage
  • Comments Comments (
    0
    ) |
Sample size 22
  • Comments Comments (
    0
    ) |
Number analyzed (intervention) 22
  • Comments Comments (
    0
    ) |
Number analyzed (control) 22
  • Comments Comments (
    0
    ) |
Baseline health 11 obese, 11 lean
  • Comments Comments (
    0
    ) |
Baseline health (coded) Mixed
  • Comments Comments (
    0
    ) |
Duration <1 d
  • Comments Comments (
    0
    ) |
Duration (coded) <1 day
  • Comments Comments (
    0
    ) |
brain 1
  • Comments Comments (
    0
    ) |
glycaemia 0
  • Comments Comments (
    0
    ) |
appetite 1
  • Comments Comments (
    0
    ) |
dietary 0
  • Comments Comments (
    0
    ) |
bodyweight 0
  • Comments Comments (
    0
    ) |
Primary (Most important outcome) hypothalamic
  • Comments Comments (
    0
    ) |
Hypotheses/Aim(s) of Study Tested 2 specific hypotheses:,1) that ingestion of sucrose is associated with engagement of hypothalamus and brain-stem vagal ,pathways, as reflected in changes in specific frequency bands,,2) obese and lean subjects differ in their central response to sucrose ingestion
  • Comments Comments (
    0
    ) |
Funding source nr
  • Comments Comments (
    0
    ) |
Funding(coded) nr
  • Comments Comments (
    0
    ) |
Internal
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.